Of giraffes' necks and the inheritance of chromatin states

New work reports that both derepressed and hyper-repressed chromatin states in animals can be transmitted to progeny for many generations. Transmission depends on genomic architecture and histone modifications.

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Figure 1: A chromosome architecture that might facilitate germline transmission of an epigenetic state.

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Correspondence to Vincenzo Pirrotta.

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Pirrotta, V. Of giraffes' necks and the inheritance of chromatin states. Nat Genet 49, 821–823 (2017). https://doi.org/10.1038/ng.3881

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