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Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures

Nature Genetics volume 49, pages1289–1291(2017)Cite this article

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References

  1. 1

    Noorbakhsh, J. & Chuang, J.H. Nat. Genet. 49, 1288–1289 (2017).

    CAS  Article  PubMed  Google Scholar 

  2. 2

    Williams, M.J., Werner, B., Barnes, C.P., Graham, T.A. & Sottoriva, A. Nat. Genet. 48, 238–244 (2016).

    CAS  Article  PubMed  Google Scholar 

  3. 3

    Donnelly, P. & Tavaré, S. Annu. Rev. Genet. 29, 401–421 (1995).

    CAS  Article  Google Scholar 

  4. 4

    Gillespie, J.H. Genetics 155, 909–919 (2000).

    CAS  PubMed Central  PubMed  Google Scholar 

  5. 5

    Kimura, M. The Neutral Theory of Molecular Evolution (Cambridge University Press, 1984).

    Google Scholar 

  6. 6

    Wu, C.-I., Wang, H.-Y., Ling, S. & Lu, X. Annu. Rev. Genet. 50, 347–369 (2016).

    CAS  Article  Google Scholar 

  7. 7

    Greaves, M. & Maley, C.C. Nature 481, 306–313 (2012).

    CAS  Article  PubMed  Google Scholar 

  8. 8

    Tomasetti, C., Marchionni, L., Nowak, M.A., Parmigiani, G. & Vogelstein, B. Proc. Natl. Acad. Sci. USA 112, 118–123 (2015).

    CAS  Article  Google Scholar 

  9. 9

    Wang, K. et al. Nat. Genet. 46, 573–582 (2014).

    CAS  Article  PubMed  Google Scholar 

Download references

Acknowledgements

A.S. is supported by the Chris Rokos Fellowship in Evolution and Cancer. B.W. is supported by the Geoffrey W. Lewis Post-Doctoral Training Fellowship. This work was supported by the Wellcome Trust (105104/Z/14/Z). C.P.B. acknowledges funding from the Wellcome Trust through a Research Career Developmental Fellowship (097319/Z/11/Z). This work was supported by a Cancer Research UK Career Developmental Award to T.A.G. M.J.W. is supported by a UK Medical Research Council student fellowship.

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Affiliations

  1. Evolution and Cancer Laboratory, Barts Cancer Institute, Queen Marry University of London, London, UK

    Marc J Williams & Trevor A Graham

  2. Department of Cell and Developmental Biology, University College London, London, UK

    Marc J Williams & Chris P Barnes

  3. Centre for Mathematics and Physics in the Life Sciences and Experimental Biology (CoMPLEX), University College London, London, UK

    Marc J Williams

  4. Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK

    Benjamin Werner & Andrea Sottoriva

  5. Department of Genetics, Evolution and Environment, University College London, London, UK

    Chris P Barnes

Authors
  1. Marc J Williams
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  2. Benjamin Werner
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  3. Chris P Barnes
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  4. Trevor A Graham
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  5. Andrea Sottoriva
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Corresponding authors

Correspondence to Trevor A Graham or Andrea Sottoriva.

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Williams, M., Werner, B., Barnes, C. et al. Reply: Uncertainties in tumor allele frequencies limit power to infer evolutionary pressures. Nat Genet 49, 1289–1291 (2017). https://doi.org/10.1038/ng.3877

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