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Nucleosome mapping in plasma DNA predicts cancer gene expression

A new study demonstrates that genomic sequencing coverage of plasma DNA fragments around transcription start sites reflects the expression levels of genes in corresponding tumors. This approach may enable noninvasive monitoring of treatment-induced changes in gene expression for patients with cancer.

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Figure 1: Sequencing coverage at transcription start sites in plasma DNA correlates with gene expression.


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Correspondence to Muhammed Murtaza or Carlos Caldas.

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Competing interests

M.M. and C.C. are inventors or contributors on patents describing methods for circulating tumor DNA analysis.

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Murtaza, M., Caldas, C. Nucleosome mapping in plasma DNA predicts cancer gene expression. Nat Genet 48, 1105–1106 (2016).

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