Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Nucleosome mapping in plasma DNA predicts cancer gene expression

A new study demonstrates that genomic sequencing coverage of plasma DNA fragments around transcription start sites reflects the expression levels of genes in corresponding tumors. This approach may enable noninvasive monitoring of treatment-induced changes in gene expression for patients with cancer.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Sequencing coverage at transcription start sites in plasma DNA correlates with gene expression.

References

  1. 1

    Snyder, M.W., Kircher, M., Hill, A.J., Daza, R.M. & Shendure, J. Cell 164, 57–68 (2016).

    CAS  Article  Google Scholar 

  2. 2

    Ulz, P. et al. Nat. Genet. 48, 1273–1278 (2016).

    CAS  Article  Google Scholar 

  3. 3

    Koh, W. et al. Proc. Natl. Acad. Sci. USA 111, 7361–7366 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Lo, Y.M. et al. Sci. Transl. Med. 2, 61ra91 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Mendel, P. et al. C. R. Hebd. Seances Acad. Sci. 226, 2019–2021 (1948).

    CAS  PubMed  Google Scholar 

  6. 6

    Bettegowda, C. et al. Sci. Transl. Med. 6, 224ra24 (2014).

    Article  Google Scholar 

  7. 7

    Diehl, F. et al. Nat. Med. 14, 985–990 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Forshew, T. et al. Sci. Transl. Med. 4, 136ra68 (2012).

    Article  Google Scholar 

  9. 9

    Newman, A.M. et al. Nat. Med. 20, 548–554 (2014).

    CAS  Article  Google Scholar 

  10. 10

    Leary, R.J. et al. Sci. Transl. Med. 4, 162ra154 (2012).

    Article  Google Scholar 

  11. 11

    Aparicio, S. & Caldas, C. N. Engl. J. Med. 368, 842–851 (2013).

    CAS  Article  Google Scholar 

  12. 12

    Dawson, S.J. et al. N. Engl. J. Med. 368, 1199–1209 (2013).

    CAS  Article  Google Scholar 

  13. 13

    Murtaza, M. et al. Nature 497, 108–112 (2013).

    CAS  Article  Google Scholar 

  14. 14

    Murtaza, M. et al. Nat. Commun. 6, 8760 (2015).

    Article  Google Scholar 

  15. 15

    Siravegna, G. et al. Nat. Med. 21, 795–801 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Muhammed Murtaza or Carlos Caldas.

Ethics declarations

Competing interests

M.M. and C.C. are inventors or contributors on patents describing methods for circulating tumor DNA analysis.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Murtaza, M., Caldas, C. Nucleosome mapping in plasma DNA predicts cancer gene expression. Nat Genet 48, 1105–1106 (2016). https://doi.org/10.1038/ng.3686

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing