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A plethora of pleiotropy across complex traits

A new analysis has identified hundreds of loci that are associated with multiple traits or diseases by comparing genome-wide association study (GWAS) data for 42 complex traits. The study uses the power of GWAS to provide evidence of pairs of traits with a likely causal relationship.

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Figure 1: Inferring causal relationship between traits based on asymmetry in GWAS results.

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Correspondence to Peter M Visscher or Jian Yang.

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Visscher, P., Yang, J. A plethora of pleiotropy across complex traits. Nat Genet 48, 707–708 (2016). https://doi.org/10.1038/ng.3604

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