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Birth and upgrowth of the Hox topological domains during evolution

The recently discovered chromatin compartments called topologically associating domains (TADs) are essential for the three-dimensional organization of regulatory interactions driving gene expression. A new study documents the emergence of a TAD flanking the amphioxus Hox cluster, prefiguring the vertebrate anterior Hox TAD and preceding the appearance of the concurring posterior Hox TAD.

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Figure 1: Schematic phylogenetic tree of bilaterian evolution showing the position of chordates, including the cephalochordate amphioxus.


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Correspondence to Jacqueline Deschamps.

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Deschamps, J. Birth and upgrowth of the Hox topological domains during evolution. Nat Genet 48, 227–228 (2016).

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