The recently discovered chromatin compartments called topologically associating domains (TADs) are essential for the three-dimensional organization of regulatory interactions driving gene expression. A new study documents the emergence of a TAD flanking the amphioxus Hox cluster, prefiguring the vertebrate anterior Hox TAD and preceding the appearance of the concurring posterior Hox TAD.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
Dixon, J.R. et al. Nature 485, 376–380 (2012).
Nora, E.P. et al. Nature 485, 381–385 (2012).
de Laat, W. & Duboule, D. Nature 502, 499–506 (2013).
Acemel, R.D. et al. Nat. Genet. 48, 336–341 (2016).
Andrey, G. et al. Science 340, 1234167 (2013).
Montavon, T. et al. Cell 147, 1132–1145 (2011).
Woltering, J.M., Noordermeer, D., Leleu, M. & Duboule, D. PLoS Biol. 12, e1001773 (2014).
Schwarzer, W. & Spitz, F. Curr. Opin. Genet. Dev. 27, 74–82 (2014).
Parker, H.J., Bronner, M.E. & Krumlauf, R. Nature 514, 490–493 (2014).
Vietri Rudan, M. et al. Cell Rep. 10, 1297–1309 (2015).
Sofueva, S. et al. EMBO J. 32, 3119–3129 (2013).
Merkenschlager, M. & Odom, D.T. Cell 152, 1285–1297 (2013).
Lonfat, N., Montavon, T., Darbellay, F., Gitto, S. & Duboule, D. Science 346, 1004–1006 (2014).
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Deschamps, J. Birth and upgrowth of the Hox topological domains during evolution. Nat Genet 48, 227–228 (2016). https://doi.org/10.1038/ng.3514