The recently discovered chromatin compartments called topologically associating domains (TADs) are essential for the three-dimensional organization of regulatory interactions driving gene expression. A new study documents the emergence of a TAD flanking the amphioxus Hox cluster, prefiguring the vertebrate anterior Hox TAD and preceding the appearance of the concurring posterior Hox TAD.
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Deschamps, J. Birth and upgrowth of the Hox topological domains during evolution. Nat Genet 48, 227–228 (2016). https://doi.org/10.1038/ng.3514
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DOI: https://doi.org/10.1038/ng.3514
