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Multisystem Lewy body disease and the other parkinsonian disorders

Nature Genetics volume 47, pages 1378–1384 (2015)Cite this article

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An Erratum to this article was published on 29 March 2016

This article has been updated

Abstract

Here we prioritize as multisystem Lewy body disease (MLBD) those genetic forms of Parkinson's disease that point the way toward a mechanistic understanding of the majority of sporadic disease. Pathological diagnosis of genetic subtypes offers the prospect of distinguishing different mechanistic trajectories with a common mutational etiology, differing outcomes from varying allelic bases, and those disease-associated variants that can be used in gene-environment analysis. Clearly delineating parkinsonian disorders into subclasses on the basis of molecular mechanisms with well-characterized outcome expectations is the basis for refining these forms of neurodegeneration as research substrate through the use of cell models derived from affected individuals while ensuring that clinically collected data can be used for therapeutic decisions and research without increasing the noise and confusion engendered by the collection of data against a range of historically defined criteria.

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Figure 1: Bubble graph of genetic forms of parkinsonism.

Change history

  • 18 December 2015

    In the version of this article initially published, four references were omitted. The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

We thank J.M. Cruz-Toledo and R. Stanley for their work on the data integration project and network-based searching, IO Informatics and The Parkinson Alliance/Parkinson's Unity Walk for generous support, and our donors and patients whose support makes this work possible.

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  1. Parkinson's Institute and Clinical Center, Sunnyvale, California, USA

    J William Langston, Birgitt Schüle, Linda Rees, R Jeremy Nichols & Carrolee Barlow

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Langston, J., Schüle, B., Rees, L. et al. Multisystem Lewy body disease and the other parkinsonian disorders. Nat Genet 47, 1378–1384 (2015). https://doi.org/10.1038/ng.3454

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