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Transcriptional mimicry by tumor-associated stroma

Nature Genetics volume 47, pages 307–309 (2015)Cite this article

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Recent molecular classification of colorectal cancer (CRC) has identified a poor-prognosis transcriptional subtype associated with mesenchymal traits. New studies used CRC transcriptomic data to show that tumor-associated stroma mimics the gene signature of epithelial-to-mesenchymal transition (EMT) and found no evidence for EMT of colorectal tumor cells.

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Figure 1: Orthogonal approaches to dissect the CRC poor-prognosis transcriptional signature.

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Authors and Affiliations

  1. Hoon Kim and Roel G.W. Verhaak are in the Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.,

    Hoon Kim & Roel G W Verhaak

  2. Roel G.W. Verhaak is also in the Department of Genomic Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.,

    Roel G W Verhaak

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  1. Hoon Kim
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  2. Roel G W Verhaak
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Correspondence to Roel G W Verhaak.

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Kim, H., Verhaak, R. Transcriptional mimicry by tumor-associated stroma. Nat Genet 47, 307–309 (2015). https://doi.org/10.1038/ng.3255

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