Deciphering mechanisms of drug resistance is crucial to winning the battle against cancer. A new study points to an unexpected function of YAP in drug resistance and illuminates its potential role as a therapeutic target.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Drug resistance and Cancer stem cells
Cell Communication and Signaling Open Access 15 February 2021
-
Emerging role of tumor cell plasticity in modifying therapeutic response
Signal Transduction and Targeted Therapy Open Access 07 October 2020
-
Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit
Scientific Reports Open Access 12 August 2019
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Vogelstein, B. et al. Science 339, 1546–1558 (2013).
Garraway, L.A. & Lander, E.S. Cell 153, 17–37 (2013).
Flaherty, K.T., Hodi, F.S. & Fisher, D.E. Nat. Rev. Cancer 12, 349–361 (2012).
Emery, C.M. et al. Proc. Natl. Acad. Sci. USA 106, 20411–20416 (2009).
Lin, L. et al. Nat. Genet. 47, 250–256 (2015).
Wang, K., Degerny, C., Xu, M. & Yang, X.J. Biochem. Cell Biol. 87, 77–91 (2009).
Overholtzer, M. et al. Proc. Natl. Acad. Sci. USA 103, 12405–12410 (2006).
Lamar, J.M. et al. Proc. Natl. Acad. Sci. USA 109, E2441–E2450 (2012).
Kapoor, A. et al. Cell 158, 185–197 (2014).
Feng, X. et al. Cancer Cell 25, 831–845 (2014).
Shao, D.D. et al. Cell 158, 171–184 (2014).
Downward, J. Nat. Rev. Cancer 3, 11–22 (2003).
Stanger, B.Z. Genes Dev. 26, 1263–1267 (2012).
Liu-Chittenden, Y. et al. Genes Dev. 26, 1300–1305 (2012).
Leung, C.H., Chan, D.S., Ma, V.P. & Ma, D.L. Med. Res. Rev. 33, 823–846 (2013).
Acknowledgements
Work in the laboratory of Y.S. is supported by the Israeli Science Foundation (1604/13; 877/13), the European Research Council (StG-335377), and the Knell and Hamburger families.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Keren-Paz, A., Emmanuel, R. & Samuels, Y. YAP and the drug resistance highway. Nat Genet 47, 193–194 (2015). https://doi.org/10.1038/ng.3228
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng.3228
This article is cited by
-
Drug resistance and Cancer stem cells
Cell Communication and Signaling (2021)
-
Emerging role of tumor cell plasticity in modifying therapeutic response
Signal Transduction and Targeted Therapy (2020)
-
Vitamin D reverts resistance to the mTOR inhibitor everolimus in hepatocellular carcinoma through the activation of a miR-375/oncogenes circuit
Scientific Reports (2019)
-
Enhanced YAP expression leads to EGFR TKI resistance in lung adenocarcinomas
Scientific Reports (2018)
-
Gastric adenocarcinoma
Nature Reviews Disease Primers (2017)