Polycomb/Trithorax response elements (PRE/TREs) are genetic elements that can stably silence or activate genes. A new study describes how long noncoding RNAs (lncRNAs) transcribed from opposite strands of the Drosophila melanogaster vestigial PRE/TRE throw the switch between these two opposing epigenetic states.
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Quinn, J., Chang, H. RNA switch at enhancers. Nat Genet 46, 929–931 (2014). https://doi.org/10.1038/ng.3074
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DOI: https://doi.org/10.1038/ng.3074
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