Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important implications for the understanding of imprinted gene networks.
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Change history
13 June 2014
In the version of this article initially published, the following sentence on page 529 referred to an incorrect locus (in bold): "In mice, the lncRNA Kcnq1ot1 associates with G9a and the polycomb repressive complex 2 (PRC2) to regulate the expression of other genes in the Dlk1-Dio3 locus in cis." The correct locus is Kcnq1. The error has been corrected in the HTML and PDF versions of the article.
References
Stelzer, Y., Sagi, I., Yanuka, O., Eiges, R. & Benvenisty, N. Nat. Genet. 46, 551–557 (2014).
Pandey, R.R. et al. Mol. Cell 32, 232–246 (2008).
Wagschal, A. et al. Mol. Cell. Biol. 28, 1104–1113 (2008).
Guttman, M. et al. Nature 458, 223–227 (2009).
Tsai, M.C. et al. Science 329, 689–693 (2010).
Gabory, A. et al. Development 136, 3413–3421 (2009).
Bartolomei, M.S., Zemel, S. & Tilghman, S.M. Nature 351, 153–155 (1991).
Monnier, P. & Dandolo, L. Med. Sci. (Paris) 29, 19–21 (2013).
Varrault, A. et al. Dev. Cell 11, 711–722 (2006).
Ribarska, T. et al. Epigenetics doi:10.4161/epi.28006 (10 February 2014).
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Murrell, A. Cross-talk between imprinted loci in Prader-Willi syndrome. Nat Genet 46, 528–530 (2014). https://doi.org/10.1038/ng.2994
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DOI: https://doi.org/10.1038/ng.2994
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Corrigendum: Cross-talk between imprinted loci in Prader-Willi syndrome
Nature Genetics (2014)
