Plasmodium falciparum in Southeast Asia are gradually becoming resistant to artemesinin, a standard first-line treatment for malaria. Whole-genome sequencing offers a chance to better understand and perhaps undermine the parasite's evolutionary response to this drug.
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
World Health Organization. World Malaria Report 2012 (World Health Organization, Geneva, 2012).
Carlton, J.M., Escalante, A.A., Neafsey, D. & Volkman, S.K. Trends Parasitol. 24, 545–550 (2008).
Dondorp, A.M. et al. N. Engl. J. Med. 361, 455–467 (2009).
Noedl, H. et al. N. Engl. J. Med. 359, 2619–2620 (2008).
Amaratunga, C. et al. Lancet Infect. Dis. 12, 851–858 (2012).
Payne, D. Parasitol. Today 3, 241–246 (1987).
Roper, C. et al. Science 305, 1124 (2004).
Mita, T. et al. J. Infect. Dis. 204, 1980–1988 (2011).
Miotto, O. et al. Nat. Genet. 45, 648–655 (2013).
Cheeseman, I.H. et al. Science 336, 79–82 (2012).
Takala-Harrison, S. et al. Proc. Natl. Acad. Sci. U.S.A. 110, 240–245 (2013).
Hastings, I.M. Trends Parasitol. 19, 70–73 (2003).
Gregson, A. & Plowe, C.V. Pharmacol. Rev. 57, 117–145 (2005).
Price, R.N. et al. Lancet 364, 438–447 (2004).
Fivelman, Q.L., Butcher, G.A., Adagu, I.S., Warhurst, D.C. & Pasvol, G. Malar. J. 1, 1 (2002).
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Neafsey, D. Genome sequencing sheds light on emerging drug resistance in malaria parasites. Nat Genet 45, 589–590 (2013). https://doi.org/10.1038/ng.2648