Letter | Published:

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry

Nature Genetics volume 45, pages 690696 (2013) | Download Citation

Abstract

Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268 individuals of African ancestry. We identified one new locus at 5q33 (GALNT10, rs7708584, P = 3.4 × 10−11) and another at 7p15 when we included data from the GIANT consortium (MIR148A-NFE2L3, rs10261878, P = 1.2 × 10−10). We also found suggestive evidence of an association at a third locus at 6q16 in the African-ancestry sample (KLHL32, rs974417, P = 6.9 × 10−8). Thirty-two of the 36 previously established BMI variants showed directionally consistent effect estimates in our GWAS (binomial P = 9.7 × 10−7), five of which reached genome-wide significance. These findings provide strong support for shared BMI loci across populations, as well as for the utility of studying ancestrally diverse populations.

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Acknowledgements

A full listing of acknowledgments is detailed in the Supplementary Note.

Author information

Author notes

    • Larry Atwood
    •  & Robert C Millikan

    Deceased.

    • Keri L Monda
    • , Gary K Chen
    • , Kira C Taylor
    • , Cameron Palmer
    •  & Todd L Edwards

    These authors contributed equally to this work.

    • Kari E North
    •  & Christopher A Haiman

    These authors jointly directed this work.

Affiliations

  1. The Center for Observational Research, Amgen, Inc. Thousand Oaks, California, USA.

    • Keri L Monda
  2. Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • Keri L Monda
    • , Kira C Taylor
    • , Mariaelisa Graff
    •  & Kari E North
  3. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

    • Gary K Chen
    • , Suhn K Rhie
    • , Graham Casey
    • , Gerhard A Coetzee
    • , Ye Feng
    • , Kristine R Monroe
    • , David J Van Den Berg
    • , Sue A Ingles
    • , Brian E Henderson
    •  & Christopher A Haiman
  4. Department of Epidemiology and Population Health, University of Louisville, Louisville, Kentucky, USA.

    • Kira C Taylor
  5. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

    • Cameron Palmer
    •  & Joel N Hirschhorn
  6. Division of Genetics, Children's Hospital, Boston, Massachusetts, USA.

    • Cameron Palmer
    •  & Joel N Hirschhorn
  7. Division of Endocrinology, Children's Hospital, Boston, Massachusetts, USA.

    • Cameron Palmer
    •  & Joel N Hirschhorn
  8. Center for Human Genetics Research, Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

    • Todd L Edwards
  9. Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.

    • Leslie A Lange
  10. Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

    • Maggie C Y Ng
    • , Nicholette D Palmer
    • , Daniel A Shriner
    • , Jie Zhou
    •  & Donald W Bowden
  11. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

    • Maggie C Y Ng
    • , Timothy D Howard
    • , Nicholette D Palmer
    •  & Donald W Bowden
  12. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA.

    • Adebowale A Adeyemo
    • , Guanjie Chen
    •  & Charles N Rotimi
  13. Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA.

    • Matthew A Allison
  14. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

    • Lawrence F Bielak
  15. Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.

    • Marguerite R Irvin
    • , Virginia J Howard
    •  & Donna K Arnett
  16. Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

    • Suhn K Rhie
    • , Graham Casey
    • , Gerhard A Coetzee
    • , David J Van Den Berg
    • , Brian E Henderson
    •  & Christopher A Haiman
  17. Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.

    • Guo Li
    • , David Siscovick
    • , Barbara McKnight
    •  & Bruce M Psaty
  18. Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

    • Yongmei Liu
  19. Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • Youfang Liu
    •  & Joanne M Jordan
  20. The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Yingchang Lu
    • , Omri Gottesman
    • , Vaneet Lotay
    • , Rajiv Nadukuru
    • , Thomas W Winkler
    • , Erwin P Bottinger
    •  & Ruth J F Loos
  21. Laboratory of Neurogenetics, National Institute on Aging (NIA), NIH, Bethesda, Maryland, USA.

    • Michael A Nalls
    • , Angela Britton
    • , Dena G Hernandez
    •  & Andrew B Singleton
  22. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

    • Yan V Sun
  23. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.

    • Mary K Wojczynski
    • , Mary F Feitosa
    •  & Ingrid B Borecki
  24. Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

    • Lisa R Yanek
    •  & Diane M Becker
  25. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

    • Melinda C Aldrich
    • , Quiyin Cai
    • , Sandra L Deming-Halverson
    • , William J Blot
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    • Melinda C Aldrich
    • , Quiyin Cai
    • , Sandra L Deming-Halverson
    • , William J Blot
    •  & Wei Zheng
  27. Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

    • Melinda C Aldrich
  28. Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.

    • Adeyinka Ademola
    •  & Temidayo O Ogundiran
  29. Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

    • Christopher I Amos
    • , Xifeng Wu
    •  & Sara S Strom
  30. Department of Family and Community Medicine, Geissel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.

    • Christopher I Amos
  31. The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.

    • Elisa V Bandera
  32. Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.

    • Cathryn H Bock
    •  & Ann G Schwartz
  33. Department of Pediatrics, Section of Genomic Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

    • Ulrich Broeckel
  34. Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA.

    • Neil E Caporaso
    • , Margaret A Tucker
    • , Regina G Ziegler
    • , Sonja I Berndt
    •  & Stephen J Chanock
  35. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

    • Chris S Carlson
    • , Suzanne Kolb
    • , Ulrike Peters
    • , Janet L Stanford
    • , Charles Kooperberg
    •  & Alex P Reiner
  36. The Translational Genomics Research Institute, Phoenix, Arizona, USA.

    • John Carpten
    •  & David Duggan
  37. Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.

    • Wei-Min Chen
    • , Fang Chen
    • , Josyf C Mychaleckyj
    •  & Uma Nayak
  38. Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA.

    • Yii-Der I Chen
    • , Xiuqing Guo
    •  & Talin Haritunians
  39. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

    • Charleston W K Chiang
    •  & Joel N Hirschhorn
  40. Department of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

    • Gerhard A Coetzee
  41. Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.

    • Ellen Demerath
    •  & Pamela J Schreiner
  42. Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.

    • Ryan W Driver
    •  & Michael J Thun
  43. South Central VA Mental Illness, Research and Clinical Center, Little Rock, Arkansas, USA.

    • Patricia Dubbert
  44. VA Geriatric Research, Education and Clinical Center, Little Rock, Arkansas, USA.

    • Patricia Dubbert
  45. Division of Health Services Research, Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

    • Patricia Dubbert
  46. Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

    • Barry I Freedman
    •  & Donald W Bowden
  47. Division of Cancer Control and Population Sciences, NCI, NIH, Bethesda, Maryland, USA.

    • Elizabeth M Gillanders
    •  & Krista A Zanetti
  48. Laboratory of Epidemiology and Population Science, NIA, NIH, Bethesda, Maryland, USA.

    • Tamara Harris
  49. Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.

    • Curtis C Harris
    • , Krista A Zanetti
    •  & Stefan Ambs
  50. Department of Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.

    • Anselm J M Hennis
    • , Barbara Nemesure
    • , Suh-Yuh Wu
    •  & M Cristina Leske
  51. Chronic Disease Research Centre, University of the West Indies, Bridgetown, Barbados.

    • Anselm J M Hennis
  52. Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados.

    • Anselm J M Hennis
  53. Ministry of Health, Bridgetown, Barbados.

    • Anselm J M Hennis
  54. Department of Health Disparities Research, Division of the Office of the Vice President (OVP), Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

    • Lorna H McNeill
  55. Center for Community-Engaged Translational Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

    • Lorna H McNeill
  56. MedStar Health Research Institute, Washington DC, USA.

    • Barbara V Howard
  57. Georgetown-Howard Universities Center for Clinical and Translational Sciences, Washington, DC, USA.

    • Barbara V Howard
  58. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

    • Karen C Johnson
  59. Henri Begleiter Neurodynamics Laboratory, Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, New York, USA.

    • Sun J Kang
  60. Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Brendan J Keating
  61. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

    • Lewis H Kuller
    •  & Joseph M Zmuda
  62. Sickle Cell Center, Department of Medicine, Georgia Health Sciences University, Augusta, Georgia, USA.

    • Abdullah Kutlar
  63. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

    • Carl D Langefeld
    •  & Kurt Lohman
  64. Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada.

    • Guillaume Lettre
  65. Program in Genomics and Endocrinology, Division of Genetics, Children's Hospital, Boston, Massachusetts, USA.

    • Helen Lyon
    •  & Amidou N'Diaye
  66. Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.

    • Helen Lyon
  67. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

    • JoAnn E Manson
  68. Regional Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

    • William Maixner
    •  & Shad B Smith
  69. Broad Institute of Harvard and MIT, Metabolic Disease Initiative, Cambridge, Massachusetts, USA.

    • Yan A Meng
  70. Center for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.

    • Imran Morhason-Bello
    •  & Oladosu Ojengbede
  71. Department of Urology, Northwestern University, Chicago, Illinois, USA.

    • Adam B Murphy
  72. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Katherine L Nathanson
  73. Department of Public Health Sciences, Henry Ford Hospital, Detroit, Michigan, USA.

    • Christine Neslund-Dudas
    • , James J Yang
    • , Albert M Levin
    •  & Benjamin A Rybicki
  74. Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

    • Marian Neuhouser
  75. Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.

    • Sarah Nyante
    •  & Robert C Millikan
  76. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA.

    • Sarah Nyante
    •  & Robert C Millikan
  77. Department of Social and Preventive Medicine, University at Buffalo, Buffalo, New York, USA.

    • Heather Ochs-Balcom
  78. Department of Medicine, University of Ibadan, Ibadan, Nigeria.

    • Adesola Ogunniyi
    •  & Babatunde Salako
  79. Department of Medicine, University of Chicago, Chicago, Illinois, USA.

    • Olufunmilayo I Olopade
    •  & Yonglan Zheng
  80. Slone Epidemiology Center at Boston University, Boston, Massachusetts, USA.

    • Julie R Palmer
    •  & Edward A Ruiz-Narvaez
  81. Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

    • Michael F Press
  82. Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.

    • Evandine Rampersaud
  83. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

    • Laura J Rasmussen-Torvik
  84. Department of Epidemiology and Public Health, University of Miami Miller School of Medicine, Miami, Florida, USA.

    • Jorge L Rodriguez-Gil
    •  & Jennifer J Hu
  85. Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, USA.

    • Jorge L Rodriguez-Gil
    •  & Jennifer J Hu
  86. Department of Genetics and Genomic Sciences, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Eric E Schadt
  87. Icahn Institute for Genomics and Multiscale Biology, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Eric E Schadt
  88. Department of Epidemiology, University of Washington, Seattle, Washington, USA.

    • David Siscovick
  89. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA.

    • Sylvia Wassertheil-Smoller
  90. Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, Michigan, USA.

    • Elizabeth K Speliotes
  91. Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA.

    • Elizabeth K Speliotes
  92. Division of Gastroenterology. Massachusetts General Hospital, Boston, Massachusetts, USA.

    • Elizabeth K Speliotes
  93. The Broad Institute, Cambridge, Massachusetts, USA.

    • Elizabeth K Speliotes
    •  & Taylor R Young
  94. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA.

    • Margaret R Spitz
  95. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.

    • Lara Sucheston
    •  & Christine B Ambrosone
  96. Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.

    • Herman Taylor
    •  & Thomas H Mosley
  97. Department of Preventive Medicine and Epidemiology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.

    • Bamidele O Tayo
    •  & Richard S Cooper
  98. Center for Human Genetics Research, Vanderbilt Epidemiology Center, Vanderbilt University, Nashville, Tennessee, USA.

    • Digna R Velez Edwards
  99. Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, Tennessee, USA.

    • Digna R Velez Edwards
  100. Core Genotype Facility, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, USA.

    • Zhaoming Wang
  101. Institute for Human Genetics, University of California San Francisco, San Francisco, California, USA.

    • John K Wiencke
    •  & Margaret Wrensch
  102. Department of Neurological Surgery, University of California San Francisco, San Francisco, California, USA.

    • John K Wiencke
    •  & Margaret Wrensch
  103. Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.

    • Thomas W Winkler
  104. Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, San Francisco, California, USA.

    • John S Witte
  105. Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont, USA.

    • Neil A Zakai
    •  & Mary Cushman
  106. Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

    • Jing Hua Zhao
    •  & Ruth J F Loos
  107. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

    • Wei Zhao
    • , Sharon L R Kardia
    •  & Patricia A Peyser
  108. Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.

    • Jyotika K Fernandes
    • , Gary S Gilkeson
    • , Diane L Kamen
    •  & Kelly J Hunt
  109. College of Nursing, Medical University of South Carolina, Charleston, South Carolina, USA.

    • Ida J Spruill
  110. Framingham Heart Study, Boston University School of Medicine, Boston, Massachusetts, USA.

    • Larry Atwood
  111. Division of Cancer Etiology, Department of Population Science, Beckman Research Institute, City of Hope, Duarte. California, USA.

    • Leslie Bernstein
  112. International Epidemiology Institute, Rockville, Maryland, USA.

    • William J Blot
  113. Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

    • Gregory Burke
    •  & Mara Vitolins
  114. Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

    • Jingzhong Ding
  115. Health Disparities Research Section, Laboratory of Population Science, NIA, NIH, Baltimore, Maryland, USA.

    • Michele K Evans
  116. National Heart, Lung and Blood Institute (NHLBI) Framingham Heart Study, Framingham, Massachusetts, USA.

    • Caroline Fox
  117. NHLBI Center for Population Studies, Framingham, Massachusetts, USA.

    • Caroline Fox
  118. Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

    • Caroline Fox
  119. Department of Nutrition Sciences, University of Alabama at Birmingham and the Birmingham VA Medical Center, Birmingham, Alabama, USA.

    • W Timothy Garvey
  120. The Center for Applied Genomics, The Children's Hospital of Philadelphia Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

    • Jonathan P Bradfield
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    •  & Struan F A Grant
  121. Division of Human Genetics, The Children's Hospital of Philadelphia Research Institute, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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    •  & Struan F A Grant
  122. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Hakon Hakonarson
    •  & Struan F A Grant
  123. Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Hakon Hakonarson
    •  & Struan F A Grant
  124. Cancer Prevention Institute of California, Fremont, California, USA.

    • Ann Hsing
    •  & Esther M John
  125. Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.

    • Ann Hsing
    •  & Esther M John
  126. Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA.

    • Ann Hsing
    • , Lisa Chu
    •  & Esther M John
  127. Department of Health Studies, University of Chicago, Chicago, Illinois, USA.

    • Dezheng Huo
  128. Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

    • Rick A Kittles
  129. Southwest Oncology Group (SWOG) Statistical Center, Seattle, Washington, USA.

    • Phyllis J Goodman
  130. Glickman Urologic and Kidney Institute, Cleveland Clinic, Cleveland, Ohio, USA.

    • Eric A Klein
  131. Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

    • Laurence N Kolonel
    •  & Loic Le Marchand
  132. Department of Epidemiology, School of Public Health, University of California at Los Angeles, Los Angeles, California, USA.

    • Simin Liu
  133. Department of Biostatistics, University of Washington, Seattle, Washington, USA.

    • Barbara McKnight
  134. Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, Michigan, USA.

    • Badri Padhukasahasram
    •  & L Keoki Williams
  135. Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan, USA.

    • L Keoki Williams
  136. Division of Sleep Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

    • Sanjay R Patel
  137. Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

    • Curtis A Pettaway
  138. Department of Epidemiology and Health Services, University of Washington, Seattle, Washington, USA.

    • Bruce M Psaty
  139. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA.

    • Bruce M Psaty
  140. Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

    • Susan Redline
  141. Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.

    • Michèle M Sale
  142. Department of Medicine, University of Virginia, Charlottesville, Virginia, USA.

    • Michèle M Sale
  143. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA.

    • Michèle M Sale
  144. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

    • Lisa B Signorello
  145. Institute for Quantitative Biomedical Sciences, The Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.

    • Jason H Moore
    •  & Scott M Williams
  146. Department of Genetics, The Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.

    • Jason H Moore
    •  & Scott M Williams
  147. Department of Community and Family Medicine, The Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.

    • Jason H Moore
  148. Division of Biology and Biomedical Sciences, Human and Statistical Genetics Program, Washington University, St. Louis, Missouri, USA.

    • Shamika Ketkar
  149. Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA.

    • Xiaofeng Zhu
  150. Behavioral Epidemiology Section, Laboratory of Population Science, NIA, NIH, Baltimore, Maryland, USA.

    • Alan B Zonderman
  151. Division of Prevention and Population Sciences, NHLBI, NIH, Bethesda, Maryland, USA.

    • George J Papanicolaou
  152. The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Ruth J F Loos
  153. The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA.

    • Ruth J F Loos

Consortia

  1. NABEC Consortium

    A list of contributing members appears in the Supplementary Note.

  2. UKBEC Consortium

    A list of contributing members appears in the Supplementary Note.

  3. BioBank Japan Project

    A list of contributing members appears in the Supplementary Note.

  4. AGEN Consortium

    A list of contributing members appears in the Supplementary Note.

Authors

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Contributions

Design and/or management of the individual studies: A.A., A.A.A., C.B.A., C.I.A., D.K.A., L.A., M.C.A., M.A.A., S.A., C.H.B., D.M.B., D.W.B., E.P.B., E.V.B., G.B., I.B.B., J.P.B., L.B., S.I.B., W.J.B., C.S.C., G. Casey, G.K.C., J.C., L.C., M.C., N.E.C., Q.C., R.S.C., S.J.C., J.D., P.D., R.W.D., S.L.D.-H., M.K.E., T.L.E., C.F., J.K.F., E.M.G., P.J.G., S.F.A.G., A.H., A.J.M.H., B.E.H., B.V.H., C.A.H., C.C.H., D.H., H.H., K.J.H., J.J.H., J.N.H., V.J.H., S.A.I., E.M.J., J.M.J., C.K., D.L.K., E.A.K., E.K.K., L.N.K., L.H.K., R.A.K., S.J.K., S. Kolb, L.L.M., A.M.L., R.J.F.L., S.L., Yongmei Liu, A.B.M., B.M., K.R.M., R.C.M., T.H.M., J.H.M., J.C.M., I.M.-B., K.E.N., M.C.Y.N., S.N., C.N.-D., U.N., B.N., K.L.N., T.O.O., O.O., O.I.O., B.P., U.P., B.M.P., C.A.P., G.J.P., J.R.P., M.F.P., P.A.P., S.R.P., E.A.R.-N., B.A.R., C.N.R., S.R., J.L.R.-G., A.B.S., A.G.S., J.L.S., L.B.S., P.J.S., S.B.S., S.W.-S., M.R.S., M.M.S., I.J.S., S.S.S., H.T., M.J.T., M.A.T., M.V., J.S.W., X.W., J.K.W., S.M.W., L.K.W., M.W., J.J.Y., N.A.Z., R.G.Z., W. Zheng, A.B.Z., K.A.Z., Y.Z. and X.Z.

Genotyping: A.B., U.B., S.J.C., Y.-D.I.C., D.D., T.L.E., S.F.A.G., X.G., D.G.H., J.N.H., T.D.H., T. Haritunians, K.C.J., Yongmei Liu, Y. Lu, W.M., R.N., J.R.P., N.D.P., S.B.S. and D.J.V.D.B.

Phenotyping: A.A.A., D.K.A., M.A.A., E.P.B., R.S.C., E.D., B.I.F., O.G., S.F.A.G., J.N.H., T. Haritunians, K.C.J., A.K., C.K., E.K.K., S.L., J.E.M., M.N., R.N., A.O., H.O.-B., B.M.P., J.R.P., S.R.P., C.N.R., E.R., S.R., B.S., D.S., L.S., B.O.T. and T.R.Y.

Statistical methods and data analysis: A.A.A., D.K.A., L.F.B., C.W.K.C., G.K.C., G. Casey, N.E.C., W.-M.C., G.A.C., Y.-D.I.C., J.D., P.D., T.L.E., C.F., M.F.F., J.P.B., E.M.G., M.G., O.G., X.G., C.A.H., M.R.I., A.K., B.J.K., C.K., E.K.K., S.J.K., C.D.L., G. Lettre, G. Li, H.L., K.L., L.A.L., R.J.F.L., V.L., Yongmei Liu, Youfang Liu, Y. Lu, B.M., K.L.M., Y.A.M., A.N., K.E.N., M.A.N., M.C.Y.N., C.P., J.R.P., E.A.R.-N., S.K.R., B.P., A.P.R., L.J.R.-T., D.A.S., E.K.S., E.E.S., Y.V.S., B.O.T., K.C.T., D.R.V.E., M.K.W., Z.W., L.K.W., T.W.W., L.R.Y., J.Z., J.H.Z., N.A.Z., J.M.Z., W. Zhao, the NABEC Consortium, the UKBEC Consortium, the BioBank Japan Project and the AGEN Consortium.

Writing group: G.K.C., T.L.E., M.G., B.E.H., J.N.H., R.J.F.L., C.A.H., L.A.L., K.L.M., K.E.N., M.C.Y.N., C.P., G.J.P., A.P.R. and K.C.T.

Critical review of the manuscript: A.A.A., A.A., C.B.A., C.I.A., D.K.A., L.A., M.A.A., M.C.A., S.A., A.B., C.H.B., D.M.B., D.W.B., E.P.B., E.V.B., G.B., I.B.B., J.P.B., L.F.B., L.B., S.I.B., U.B., W.J.B., C.W.K.C., C.S.C., F.C., G.A.C., G.K.C., G. Casey, G. Chen, J.C., L.C., M.C., N.E.C., Q.C., R.S.C., S.J.C., W.-M.C., Y.-D.I.C., D.D., E.D., J.D., P.D., R.W.D., S.L.D.-H., M.K.E., T.L.E., C.F., J.K.F., M.F.F., B.I.F., Y.F., E.M.G., G.S.G., M.G., O.G., P.J.G., S.F.A.G., W.T.G., X.G., A.J.M.H., A.H., B.E.H., B.V.H., C.A.H., C.C.H., D.G.H., D.H., H.H., J.J.H., J.N.H., K.J.H., T.D.H., T. Haritunians, T. Harris, V.J.H., J.H.M., M.R.I., S.A.I., E.M.J., J.M.J., K.C.J., A.K., B.J.K., C.K., D.L.K., E.A.K., E.K.K., L.N.K., L.H.K., R.A.K., S.J.K., S.L.R.K., S. Kolb, S. Ketkar, A.M.L., C.D.L., G. Lettre, G. Li, H.L., K.L., L.A.L., L.L., M.C.L., R.J.F.L., S.L., V.L., Yongmei Liu, Youfang Liu, Y. Lu, A.B.M., B.M., J.C.M., J.E.M., L.H.M., K.L.M., K.R.M., R.C.M., T.H.M., W.M., Y.A.M., I.M.-B., A.N., B.N., K.E.N., K.L.N., M.A.N., M.C.Y.N., M.N., R.N., S.N., U.N., C.N.-D., O.I.O., O.O., T.O.O., A.O., H.O.-B., B.M.P., B.P., C.A.P., C.P., G.J.P., J.R.P., M.F.P., N.D.P., P.A.P., S.R.P., U.P., A.P.R., B.A.R., C.N.R., E.R., S.K.R., S.R., J.L.R.-G., E.A.R.-N., L.J.R.-T., A.B.S., A.G.S., B.S., D.A.S., D.S., E.K.S., E.E.S., I.J.S., J.L.S., L.B.S., L.S., M.M.S., M.R.S., P.J.S., S.B.S., S.S.S., Y.V.S., B.O.T., K.C.T., M.A.T., H.T., M.J.T., M.V., D.J.V.D.B., D.R.V.E., J.K.W., M.W., S.M.W., S.-Y.W., S.W.-S., T.W.W., X.W., Z.W., L.K.W., J.S.W., M.K.W., J.J.Y., L.R.Y., T.R.Y., A.B.Z., J.Z., J.M.Z., J.H.Z., K.A.Z., N.A.Z., R.G.Z., W. Zhao, W Zheng, X.Z. and Y.Z.

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Kari E North or Christopher A Haiman.

Supplementary information

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  1. 1.

    Supplementary Text and Figures

    Supplementary Tables 1–18, Supplementary Figures 1–9 and Supplementary Note

Excel files

  1. 1.

    Supplementary Table 19

    Comprehensive results of the biofeature analysis for the three novel loci

About this article

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DOI

https://doi.org/10.1038/ng.2608

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