Article | Published:

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Nature Genetics volume 45, pages 371384 (2013) | Download Citation

Abstract

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed 480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10−7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10−8) and BRCA1 mutation carrier (P = 1.1 × 10−5) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10−14), higher risk of low-malignant-potential ovarian cancer (P = 1.3 × 10−15) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 × 10−12) and BRCA1 mutation carrier (P = 1.6 × 10−14) breast and invasive ovarian (P = 1.3 × 10−11) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.

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References

  1. 1.

    , & Telomeres and their control. Annu. Rev. Genet. 34, 331–358 (2000).

  2. 2.

    & How shelterin protects mammalian telomeres. Annu. Rev. Genet. 42, 301–334 (2008).

  3. 3.

    Telomeres. Exp. Gerontol. 41, 1223–1227 (2006).

  4. 4.

    et al. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85, 6622–6626 (1988).

  5. 5.

    et al. Telomere length predicts replicative capacity of human fibroblasts. Proc. Natl. Acad. Sci. USA 89, 10114–10118 (1992).

  6. 6.

    Telomere loss: mitotic clock or genetic time bomb? Mutat. Res. 256, 271–282 (1991).

  7. 7.

    et al. Telomere end-replication problem and cell aging. J. Mol. Biol. 225, 951–960 (1992).

  8. 8.

    et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921–1929 (1992).

  9. 9.

    et al. Telomerase activity in human breast tumors. J. Natl. Cancer Inst. 88, 116–122 (1996).

  10. 10.

    & Human epithelial cell immortalization as a step in carcinogenesis. Cancer Lett. 194, 199–208 (2003).

  11. 11.

    et al. Telomere length is associated with disease severity and declines with age in dyskeratosis congenita. Haematologica 97, 353–359 (2012).

  12. 12.

    et al. Telomere length is paternally inherited and is associated with parental lifespan. Proc. Natl. Acad. Sci. USA 104, 12135–12139 (2007).

  13. 13.

    , & Genetic determination of telomere size in humans: a twin study of three age groups. Am. J. Hum. Genet. 55, 876–882 (1994).

  14. 14.

    et al. The association of telomere length and genetic variation in telomere biology genes. Hum. Mutat. 31, 1050–1058 (2010).

  15. 15.

    et al. No association between TERT-CLPTM1L single nucleotide polymorphism rs401681 and mean telomere length or cancer risk. Cancer Epidemiol. Biomarkers Prev. 19, 1862–1865 (2010).

  16. 16.

    et al. Telomerase reverse transcriptase locus polymorphisms and cancer risk: a field synopsis and meta-analysis. J. Natl. Cancer Inst. 104, 840–854 (2012).

  17. 17.

    et al. Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. Aging Cell 11, 223–227 (2012).

  18. 18.

    et al. Telomere length, cigarette smoking, and bladder cancer risk in men and women. Cancer Epidemiol. Biomarkers Prev. 16, 815–819 (2007).

  19. 19.

    et al. Telomere length in prospective and retrospective cancer case-control studies. Cancer Res. 70, 3170–3176 (2010).

  20. 20.

    et al. Telomere length, oxidative damage, antioxidants and breast cancer risk. Int. J. Cancer 124, 1637–1643 (2009).

  21. 21.

    et al. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 20, 1238–1250 (2011).

  22. 22.

    et al. A prospective study of relative telomere length and postmenopausal breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 18, 1152–1156 (2009).

  23. 23.

    et al. Mean telomere length and risk of incident colorectal carcinoma: a prospective, nested case-control approach. Cancer Epidemiol. Biomarkers Prev. 18, 2280–2282 (2009).

  24. 24.

    Variation at the TERT locus and predisposition for cancer. Expert Rev. Mol. Med. 12, e16 (2010).

  25. 25.

    et al. Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLoS ONE 6, e24987 (2011).

  26. 26.

    et al. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat. Genet. 43, 785–791 (2011).

  27. 27.

    et al. A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am. J. Hum. Genet. 85, 679–691 (2009).

  28. 28.

    et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types. Nat. Genet. 41, 221–227 (2009).

  29. 29.

    et al. Genome-wide association study identifies five susceptibility loci for glioma. Nat. Genet. 41, 899–904 (2009).

  30. 30.

    et al. New common variants affecting susceptibility to basal cell carcinoma. Nat. Genet. 41, 909–914 (2009).

  31. 31.

    et al. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat. Genet. 42, 604–607 (2010).

  32. 32.

    et al. Common 5p15.33 and 6p21.33 variants influence lung cancer risk. Nat. Genet. 40, 1407–1409 (2008).

  33. 33.

    et al. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility “hot-spot”. PLoS Genet. 6, e1001016 (2010).

  34. 34.

    et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer. Nat. Genet. 43, 1210–1214 (2011).

  35. 35.

    1000 Genomes Project Consortium. A map of human genome variation from population-scale sequencing. Nature 467, 1061–1073 (2010).

  36. 36.

    et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat. Genet. published online; doi:10.1038/ng.2563 (27 March 2013).

  37. 37.

    et al. GWAS meta-analysis and replication identifies three new common susceptibility loci for ovarian cancer. Nat. Genet. published online; doi:10.1038/ng.2564 (27 March 2013).

  38. 38.

    et al. Genome-wide association studies identify four ER negative–specific breast cancer risk loci. Nat. Genet. published online; doi:10.1038/ng.2561 (27 March 2013).

  39. 39.

    et al. ENCODE whole-genome data in the UCSC Genome Browser: update 2012. Nucleic Acids Res. 40, D912–D917 (2012).

  40. 40.

    et al. FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin. Genome Res. 17, 877–885 (2007).

  41. 41.

    et al. ESPERR: learning strong and weak signals in genomic sequence alignments to identify functional elements. Genome Res. 16, 1596–1604 (2006).

  42. 42.

    et al. Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 15, 907–913 (2009).

  43. 43.

    et al. PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res. 68, 5724–5732 (2008).

  44. 44.

    et al. The hTERTα splice variant is a dominant negative inhibitor of telomerase activity. Neoplasia 2, 426–432 (2000).

  45. 45.

    , & Characterization of novel alternative splicing sites in human telomerase reverse transcriptase (hTERT): analysis of expression and mutual correlation in mRNA isoforms from normal and tumour tissues. BMC Mol. Biol. 7, 26 (2006).

  46. 46.

    et al. Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types. Hum. Mol. Genet. 6, 2011–2019 (1997).

  47. 47.

    , & Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT). Gene 232, 97–106 (1999).

  48. 48.

    et al. Human Splicing Finder: an online bioinformatics tool to predict splicing signals. Nucleic Acids Res. 37, e67 (2009).

  49. 49.

    Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature 474, 609–615 (2011).

  50. 50.

    et al. Short telomere length, myocardial infarction, ischemic heart disease, and early death. Arterioscler. Thromb. Vasc. Biol. 32, 822–829 (2012).

  51. 51.

    et al. Common variants near TERC are associated with mean telomere length. Nat. Genet. 42, 197–199 (2010).

  52. 52.

    et al. Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology. Proc. Natl. Acad. Sci. USA 107, 9293–9298 (2010).

  53. 53.

    et al. Telomere length and risk of incident cancer and cancer mortality. J. Am. Med. Assoc. 304, 69–75 (2010).

  54. 54.

    et al. Fine-mapping identifies multiple prostate cancer risk loci on 5p15, one of which associates with TERT expression. Hum. Mol. Genet. published online; doi:10.1093/hmg/ddt086 (27 March 2013).

  55. 55.

    et al. Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc. Natl. Acad. Sci. USA 98, 12072–12077 (2001).

  56. 56.

    et al. Senescent fibroblasts promote neoplastic transformation of partially transformed ovarian epithelial cells in a three-dimensional model of early stage ovarian cancer. Neoplasia 12, 317–325 (2010).

  57. 57.

    et al. Lung cancer susceptibility locus at 5p15.33. Nat. Genet. 40, 1404–1406 (2008).

  58. 58.

    et al. Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 19, 219–228 (2010).

  59. 59.

    et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat. Genet. 43, 792–796 (2011).

  60. 60.

    et al. A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis. J. Med. Genet. 45, 654–656 (2008).

  61. 61.

    et al. Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J. Natl. Cancer Inst. 102, 959–971 (2010).

  62. 62.

    et al. The TERT rs2736100 polymorphism and cancer risk: a meta-analysis based on 25 case-control studies. BMC Cancer 12, 7 (2012).

  63. 63.

    et al. Fine-mapping of a region of chromosome 5p15.33 (TERT-CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese population. Int. J. Cancer 129, 2463–2472 (2011).

  64. 64.

    et al. Telomere lengths are characteristic in each human individual. Exp. Gerontol. 37, 523–531 (2002).

  65. 65.

    et al. Telomere length in blood, buccal cells, and fibroblasts from patients with inherited bone marrow failure syndromes. Aging (Albany. NY) 2, 867–874 (2010).

  66. 66.

    , & Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease. Mech. Ageing Dev. 129, 183–190 (2008).

  67. 67.

    & Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405–413 (1985).

  68. 68.

    et al. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 4, e10 (2008).

  69. 69.

    et al. Telomerase modulates Wnt signalling by association with target gene chromatin. Nature 460, 66–72 (2009).

  70. 70.

    et al. Separation of telomerase functions by reverse genetics. Proc. Natl. Acad. Sci. USA 108, E1363–E1371 (2011).

  71. 71.

    et al. Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk. PLoS Genet. 9, e1003173 (2013).

  72. 72.

    et al. Association between a germline OCA2 polymorphism at chromosome 15q13.1 and estrogen receptor–negative breast cancer survival. J. Natl. Cancer Inst. 102, 650–662 (2010).

  73. 73.

    , & Integrin β3 Leu33Pro homozygosity and risk of cancer. J. Natl. Cancer Inst. 95, 1150–1157 (2003).

  74. 74.

    , & Baseline C-reactive protein is associated with incident cancer and survival in patients with cancer. J. Clin. Oncol. 27, 2217–2224 (2009).

  75. 75.

    et al. C-reactive protein and the risk of cancer: a mendelian randomization study. J. Natl. Cancer Inst. 102, 202–206 (2010).

  76. 76.

    et al. Genetically elevated C-reactive protein and ischemic vascular disease. N. Engl. J. Med. 359, 1897–1908 (2008).

  77. 77.

    et al. Estimating local ancestry in admixed populations. Am. J. Hum. Genet. 82, 290–303 (2008).

  78. 78.

    et al. Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer risk. Cancer Epidemiol. Biomarkers Prev. 21, 504–512 (2012).

  79. 79.

    Telomere measurement by quantitative PCR. Nucleic Acids Res. 30, e47 (2002).

  80. 80.

    Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res. 37, e21 (2009).

  81. 81.

    et al. Evaluation of association methods for analysing modifiers of disease risk in carriers of high-risk mutations. Genet. Epidemiol. 36, 274–291 (2012).

  82. 82.

    et al. A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population. Nat. Genet. 42, 885–892 (2010).

  83. 83.

    et al. A weighted cohort approach for analysing factors modifying disease risks in carriers of high-risk susceptibility genes. Genet. Epidemiol. 29, 1–11 (2005).

  84. 84.

    et al. A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat. Med. 14, 1384–1389 (2008).

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Acknowledgements

We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out. COGS is funded through a grant from the European Commission's Seventh Framework Programme (agreement 223175–HEALTH-F2-2009-223175). BCAC is funded by Cancer Research UK (C1287/A10118 and C1287/A12014). BCAC meetings have been funded by the European Union Cooperation in Science and Technology (COST) programme (BM0606). Telomere length measurement and analysis were funded by Cancer Research UK project grant C1287/A9540 and Chief Physician Johan Boserup and Lise Boserup's Fund. CIMBA data management and analysis were supported by Cancer Research UK grants C12292/A11174 and C1287/A10118. OCAC is supported by a grant from the Ovarian Cancer Research Fund thanks to the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). Genotyping of the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer program (J.S. and D.E.) and the Ministry of Economic Development, Innovation and Export Trade of Quebec (grant PSR-SIIRI-701; J.S., D.E. and P. Hall). Scientific development and funding of the OCAC portion of this project were supported by Genetic Associations and Mechanisms in Oncology (GAME-ON; U19-CA148112). CIMBA genotyping was supported by US National Institutes of Health (NIH) grant CA128978, a National Cancer Institute (NCI) Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a US Department of Defense Ovarian Cancer Idea award (W81XWH-10-1-0341) and grants from the Breast Cancer Research Foundation and the Komen Foundation for the Cure. This study made use of data generated by The Wellcome Trust Case Control Consortium (funding was provided by Wellcome Trust award 076113) and the TCGA Pilot Project established by NCI and the National Human Genome Research Institute.

Author information

Author notes

    • Stig E Bojesen
    • , Karen A Pooley
    • , Sharon E Johnatty
    • , Jonathan Beesley
    • , Kyriaki Michailidou
    •  & Jonathan P Tyrer

    These authors contributed equally to this work.

    • Douglas F Easton
    • , Andrew Berchuck
    • , Antonis C Antoniou
    • , Georgia Chenevix-Trench
    •  & Alison M Dunning

    These authors jointly directed this work.

Affiliations

  1. Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.

    • Stig E Bojesen
    • , Maren Weischer
    • , Sune F Nielsen
    •  & Børge G Nordestgaard
  2. Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.

    • Stig E Bojesen
    • , Maren Weischer
    • , Sune F Nielsen
    •  & Børge G Nordestgaard
  3. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

    • Karen A Pooley
    • , Kyriaki Michailidou
    • , Manjeet K Bolla
    • , Qin Wang
    • , Joe Dennis
    • , Lesley McGuffog
    • , Daniel Barrowdale
    • , Andrew Lee
    • , Michael Lush
    • , Judith Brown
    • , Robert Luben
    • , Susan Peock
    • , Debra Frost
    • , Elena Fineberg
    • , Radka Platte
    • , Steve D Ellis
    • , Karoline B Kuchenbaecker
    • , Ed Dicks
    • , Douglas F Easton
    •  & Antonis C Antoniou
  4. Department of Genetics, Queensland Institute of Medical Research, Brisbane, Queensland, Australia.

    • Sharon E Johnatty
    • , Jonathan Beesley
    • , Yi Lu
    • , Xiaoqing Chen
    • , Sue Healey
    • , Amanda B Spurdle
    •  & Georgia Chenevix-Trench
  5. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

    • Jonathan P Tyrer
    • , Melanie J Maranian
    • , Maya Ghoussaini
    • , Shahana Ahmed
    • , Caroline Baynes
    • , Mitul Shah
    • , Honglin Song
    • , Catherine S Healey
    • , Craig Luccarini
    • , Paul D P Pharoah
    • , Douglas F Easton
    •  & Alison M Dunning
  6. School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland, Australia.

    • Stacey L Edwards
    • , Kristine M Hillman
    •  & Juliet D French
  7. Cancer Research Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

    • Hilda A Pickett
    • , Michael D Stutz
    •  & Roger R Reddel
  8. Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

    • Hilda A Pickett
    • , Michael D Stutz
    •  & Roger R Reddel
  9. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

    • Howard C Shen
    • , Kate Lawrenson
    • , Rod Karevan
    • , Christopher A Haiman
    • , Anna H Wu
    • , Brian E Henderson
    • , Fredrick Schumacher
    • , Susan J Ramus
    • , Celeste L Pearce
    • , Malcolm C Pike
    • , Chiu-Chen Tseng
    • , Daniel O Stram
    • , David van den Berg
    •  & Simon A Gayther
  10. University of Queensland, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

    • Chanel E Smart
    • , Rebecca L Johnston
    •  & Sunil R Lakhani
  11. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA.

    • Phuong L Mai
    • , Sharon A Savage
    •  & Mark H Greene
  12. Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.

    • Nicholas Woods
    • , Catherine M Phelan
    • , Jenny Permuth-Wey
    • , Thomas A Sellers
    •  & Alvaro N A Monteiro
  13. McGill University and Génome Québec Innovation Centre, Montréal, Quebec, Canada.

    • Daniel C Tessier
    • , Daniel Vincent
    •  & Françis Bacot
  14. Department of Obstetrics and Gynaecology, Division of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium.

    • Ignace Vergote
    • , Sandrina Lambrechts
    •  & Evelyn Despierre
  15. Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.

    • Ignace Vergote
    • , Sandrina Lambrechts
    •  & Evelyn Despierre
  16. Department of Epidemiology and Public Health, Yale University School of Public Health and School of Medicine, New Haven, Connecticut, USA.

    • Harvey A Risch
  17. Centro Nacional de Genotipación, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.

    • Anna González-Neira
    • , Guillermo Pita
    • , Nuria Álvarez
    •  & Javier Benitez
  18. Department of Epidemiology, University of Washington, Seattle, Washington, USA.

    • Mary Anne Rossing
  19. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

    • Mary Anne Rossing
  20. Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

    • Jennifer A Doherty
  21. Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA.

    • Melissa C Larson
    • , Sebastian M Armasu
    •  & Robert A Vierkant
  22. Kansas IDeA Network of Biomedical Research Excellence Bioinformatics Core, The University of Kansas Cancer Center, Kansas City, Kansas, USA.

    • Brooke L Fridley
  23. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

    • Nils Schoof
    • , Mikael Hartman
    • , Kamila Czene
    • , Keith Humphreys
    •  & Per Hall
  24. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

    • Jenny Chang-Claude
    • , Rebecca Hein
    • , Anja Rudolph
    •  & Stefan Nickels
  25. Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.

    • Mine S Cicek
    •  & Ellen L Goode
  26. Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

    • Julian Peto
    • , Isabel Dos Santos Silva
    •  & Lorna Gibson
  27. Department of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA.

    • Kimberly R Kalli
  28. Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

    • Annegien Broeks
    • , Marjanka K Schmidt
    • , Linde M Braaf
    •  & Matti A Rookus
  29. Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

    • Marjanka K Schmidt
  30. Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota, USA.

    • Boris Winterhoff
    • , Lisa Rogmann
    •  & Attila Teoman
  31. Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

    • Heli Nevanlinna
    • , Ralf Butzow
    • , Liisa M Pelttari
    • , Arto Leminen
    •  & Taru A Muranen
  32. Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

    • Gottfried E Konecny
    •  & Peter A Fasching
  33. Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.

    • Diether Lambrechts
    •  & Els Wauters
  34. Vesalius Research Center (VRC), VIB, Leuven, Belgium.

    • Diether Lambrechts
    •  & Els Wauters
  35. Institut National de la Santé et de la Recherche Médicale (INSERM) U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France.

    • Pascal Guénel
    •  & Thérèse Truong
  36. University Paris–Sud, Unité Mixte de Recherche Scientifique (UMRS) 1018, Villejuif, France.

    • Pascal Guénel
    •  & Thérèse Truong
  37. Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, CNIO, Madrid, Spain.

    • Roger L Milne
  38. Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, Minnesota, USA.

    • Joaquin J Garcia
    • , Vijayalakshmi Shridhar
    • , Xianshu Wang
    • , Julie M Cunningham
    •  & Fergus J Couch
  39. Cancer Research UK/Yorkshire Cancer Research Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, UK.

    • Angela Cox
    •  & Sabapathy P Balasubramanian
  40. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.

    • Barbara Burwinkel
    • , Frederik Marme
    • , Andreas Schneeweiss
    •  & Christof Sohn
  41. Molecular Epidemiology Group, DKFZ, Heidelberg, Germany.

    • Barbara Burwinkel
  42. National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.

    • Frederik Marme
    •  & Andreas Schneeweiss
  43. Primärmedizinische Versorgung (PMV) Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.

    • Rebecca Hein
  44. Division of Cancer Studies, National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre, Guy's & St. Thomas' National Health Service (NHS) Foundation Trust in partnership with King's College London, London, UK.

    • Elinor J Sawyer
  45. Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.

    • Shan Wang-Gohrke
    •  & Helmut Deissler
  46. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

    • Irene L Andrulis
  47. Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

    • Irene L Andrulis
  48. Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.

    • Kirsten B Moysich
    •  & Kunle Odunsi
  49. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia.

    • John L Hopper
    • , Graham G Giles
    • , Carmel Apicella
    • , Gianluca Severi
    •  & Laura Baglietto
  50. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

    • Annika Lindblom
  51. Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria, Australia.

    • Graham G Giles
    • , Gianluca Severi
    •  & Laura Baglietto
  52. Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

    • Graham G Giles
  53. Division of Clinical Epidemiology and Aging Research, DKFZ, Heidelberg, Germany.

    • Hermann Brenner
    • , Heiko Müller
    •  & Volker Arndt
  54. Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec City, Quebec, Canada.

    • Jacques Simard
    • , Martine Dumont
    •  & Penny Soucy
  55. Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

    • Galina Lurie
    • , Michael E Carney
    • , Lynne R Wilkens
    •  & Loic Le Marchand
  56. Department of Gynecology and Obstetrics, University Breast Center for Franconia Erlangen University Hospital, Erlangen, Germany.

    • Peter A Fasching
    • , Matthias W Beckmann
    •  & Michael P Lux
  57. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Nazionale Tumori (INT), Milan, Italy.

    • Paolo Radice
    •  & Paolo Peterlongo
  58. Istituto Fondazione Italiana per la Ricerca sul Cancro di Oncologia Molecolare, Milan, Italy.

    • Paolo Radice
    • , Filomena Ficarazzi
    •  & Paolo Peterlongo
  59. Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.

    • Anthony Swerdlow
    •  & Michael Jones
  60. Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, UK.

    • Anthony Swerdlow
  61. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

    • Marc T Goodman
  62. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.

    • Hiltrud Brauch
  63. Faculty of Medicine, University of Tübingen, Tübingen, Germany.

    • Hiltrud Brauch
  64. Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.

    • Montserrat Garcia-Closas
    • , Olivia Fletcher
    • , Alan Ashworth
    •  & Nick Orr
  65. Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.

    • Peter Hillemanns
  66. Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland.

    • Robert Winqvist
    •  & Katri Pylkäs
  67. Biocenter Oulu, University of Oulu, Oulu, Finland.

    • Robert Winqvist
    •  & Katri Pylkäs
  68. Department of Gynecology, Jena University Hospital, Jena, Germany.

    • Matthias Dürst
    •  & Ingo Runnebaum
  69. Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

    • Peter Devilee
  70. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

    • Peter Devilee
  71. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.

    • Anna Jakubowska
    • , Jan Lubinski
    • , Katarzyna Durda
    • , Katarzyna Jaworska
    • , Aleksandra Toloczko-Grabarek
    • , Jacek Gronwald
    •  & Tomasz Byrski
  72. Department of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, Finland.

    • Arto Mannermaa
    • , Jaana M Hartikainen
    •  & Veli-Matti Kosma
  73. School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.

    • Arto Mannermaa
    • , Jaana M Hartikainen
    • , Veli-Matti Kosma
    •  & Vesa Kataja
  74. Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland.

    • Ralf Butzow
  75. Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.

    • Natalia V Bogdanova
    •  & Thilo Dörk
  76. Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.

    • Natalia V Bogdanova
    •  & Qiuyin Cai
  77. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

    • Wei Zheng
    • , Xiao-Ou Shu
    • , William Blot
    • , Gong Yang
    • , Jirong Long
    • , Martha Shrubsole
    • , Sandra Deming-Halverson
    • , Hui Cai
    •  & Lisa B Signorello
  78. Department of Epidemiology, University of California–Irvine, Irvine, California, USA.

    • Hoda Anton-Culver
  79. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

    • Clareann H Bunker
  80. Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.

    • Vessela Kristensen
  81. Faculty of Medicine (Faculty Division Ahus), Universitetet i Oslo, Oslo, Norway.

    • Vessela Kristensen
  82. The University of Texas School of Public Health, Houston, Texas, USA.

    • Roberta B Ness
  83. Warwick Medical School, Warwick University, Coventry, UK.

    • Kenneth Muir
    • , Artitaya Lophatananon
    •  & Sarah Stewart-Brown
  84. Institute of Population Health, University of Manchester, Manchester, UK.

    • Kenneth Muir
    •  & Artitaya Lophatananon
  85. Maggee Women's Hospital, Pittsburgh, Pennsylvania, USA.

    • Robert Edwards
  86. Department of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.

    • Alfons Meindl
  87. Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany.

    • Florian Heitz
    • , Andreas du Bois
    •  & Philipp Harter
  88. Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany.

    • Florian Heitz
    • , Andreas du Bois
    •  & Philipp Harter
  89. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.

    • Keitaro Matsuo
    • , Satoyo Hosono
    • , Hidemi Ito
    •  & Kazuo Tajima
  90. Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia.

    • Soo-Hwang Teo
  91. Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.

    • Soo-Hwang Teo
    • , Cheng Har Yip
    •  & Yew-Ching Teh
  92. Institut für Humangenetik Wiesbaden, Wiesbaden, Germany.

    • Ira Schwaab
  93. International Epidemiology Institute, Rockville, Maryland, USA.

    • William Blot
    •  & Lisa B Signorello
  94. Seoul National University College of Medicine, Seoul, Korea.

    • Daehee Kang
    • , Dong-Young Noh
    •  & Keun-Young Yoo
  95. Department of Gynecologic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Japan.

    • Toru Nakanishi
  96. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

    • Mikael Hartman
    •  & Philip Tsau-Choong Iau
  97. Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

    • Mikael Hartman
    • , Hui Miao
    •  & Yik Ying Teo
  98. Department of Pathology and Molecular Diagnostic, Aichi Cancer Center Central Hospital, Nagoya, Japan.

    • Yasushi Yatabe
  99. Molecular Genetics of Breast Cancer, DKFZ, Heidelberg, Germany.

    • Ute Hamann
  100. Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.

    • Beth Y Karlan
    •  & Jenny Lester
  101. Research Division, National Cancer Institute, Bangkok, Thailand.

    • Suleeporn Sangrajrang
  102. Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

    • Susanne Krüger Kjaer
    • , Allan Jensen
    •  & Estrid Høgdall
  103. The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark.

    • Susanne Krüger Kjaer
    •  & Claus K Høgdall
  104. International Agency for Research on Cancer, Lyon, France.

    • Valerie Gaborieau
    •  & James McKay
  105. Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK.

    • Diana Eccles
  106. Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.

    • Estrid Høgdall
  107. Colleague of Public Health, China Medical University, Taichong, Taiwan.

    • Chen-Yang Shen
  108. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

    • Chen-Yang Shen
    •  & Chia-Ni Hsiung
  109. Department of Obstetrics and Gynaecology, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.

    • Yin Ling Woo
    • , Mat Adenan Noor Azmi
    •  & Siti Zawiah Omar
  110. Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.

    • Henrik Flyger
  111. Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.

    • Celine Vachon
    • , Janet E Olson
    • , Curtis Olswold
    • , Susan Slager
    • , Vernon S Pankratz
    •  & Fergus J Couch
  112. Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

    • Douglas A Levine
  113. Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA.

    • Rachel Palmieri Weber
    •  & Joellen M Schildkraut
  114. Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg–Eppendorf, Hamburg, Germany.

    • Dieter Flesch-Janys
  115. Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg–Eppendorf, Hamburg, Germany.

    • Dieter Flesch-Janys
  116. Department of Statistical Science, Duke University, Durham, North Carolina, USA.

    • Edwin Iversen
  117. Cancer Prevention, Detection and Control Research Program, Duke Cancer Institute, Durham, North Carolina, USA.

    • Edwin Iversen
    •  & Joellen M Schildkraut
  118. Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

    • Daniel W Cramer
    • , Kathryn L Terry
    •  & Allison F Vitonis
  119. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.

    • Daniel W Cramer
    • , Kathryn L Terry
    • , Elizabeth M Poole
    •  & Shelley S Tworoger
  120. Sanquin Research, Amsterdam, The Netherlands.

    • C Ellen van der Schoot
  121. Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, Massachusetts, USA.

    • Elizabeth M Poole
    •  & Shelley S Tworoger
  122. Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

    • Frans B L Hogervorst
  123. Division of Human Genetics, Genome Institute of Singapore, Singapore.

    • Jianjun Liu
    •  & Jingmei Li
  124. The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.

    • Elisa V Bandera
    •  & Lorna Rodriguez-Rodriguez
  125. Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

    • Sara H Olson
    • , Irene Orlow
    •  & Malcolm C Pike
  126. Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.

    • Carl Blomqvist
  127. Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.

    • Kristiina Aittomäki
  128. Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.

    • Helga B Salvesen
    • , Elisabeth Wik
    • , Camilla Krakstad
    •  & Mari K Halle
  129. Department of Clinical Medicine, University of Bergen, Bergen, Norway.

    • Helga B Salvesen
    • , Elisabeth Wik
    • , Camilla Krakstad
    •  & Mari K Halle
  130. Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.

    • Barbara Brouwers
  131. Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.

    • Barbara Brouwers
    •  & Hans Wildiers
  132. Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands.

    • Lambertus A Kiemeney
    •  & Katja K Aben
  133. Department of Epidemiology, Biostatistics and Health Technology Assessment, Radboud University Medical Centre, Nijmegen, The Netherlands.

    • Lambertus A Kiemeney
    •  & Katja K Aben
  134. Department of Urology, Radboud University Medical Centre, Nijmegen, The Netherlands.

    • Lambertus A Kiemeney
  135. Université Paris Sorbonne Cité, Unité Mixte de Recherche (UMR) S775, INSERM, Paris, France.

    • Claire Mulot
    •  & Pierre Laurent-Puig
  136. Department of Gynecology, Radboud University Medical Centre, Nijmegen, The Netherlands.

    • Anne Mvan Altena
    •  & Leon F A G Massuger
  137. Human Genetics Group, CNIO, Madrid, Spain.

    • Javier Benitez
  138. Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.

    • Javier Benitez
  139. Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA.

    • Tanja Pejovic
  140. Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA.

    • Tanja Pejovic
  141. Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.

    • Jose Ignacio Arias Perez
  142. Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, Oregon, USA.

    • Maureen Hoatlin
  143. Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.

    • M Pilar Zamora
  144. Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, New Mexico, USA.

    • Linda S Cook
  145. Department of Population Health Research, Alberta Health Services–Cancer Care, Calgary, Alberta, Canada.

    • Linda E Kelemen
  146. Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada.

    • Linda E Kelemen
  147. Department of Oncology, University of Calgary, Calgary, Alberta, Canada.

    • Linda E Kelemen
  148. Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

    • Nhu D Le
  149. Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

    • Angela Brooks-Wilson
  150. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

    • Angela Brooks-Wilson
  151. Welcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

    • Ian Tomlinson
  152. Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

    • Ian Tomlinson
  153. School of Medicine, National University of Ireland, Galway, Ireland.

    • Michael J Kerin
    •  & Nicola Miller
  154. International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical Academy, Szczecin, Poland.

    • Cezary Cybulski
  155. Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland.

    • Janusz Menkiszak
  156. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

    • Nicolas Wentzensen
    • , Hannah P Yang
    • , Jonine Figueroa
    •  & Stephen J Chanock
  157. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

    • Anna Marie Mulligan
  158. Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

    • Anna Marie Mulligan
  159. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

    • Gord Glendon
    •  & John R McLaughlin
  160. Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

    • Svend Aage Engelholm
  161. Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

    • Julia A Knight
  162. Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.

    • Julia A Knight
  163. Gynecological Oncology Unit, The Royal Marsden Hospital, London, UK.

    • Martin Gore
  164. Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia.

    • Helen Tsimiklis
    •  & Melissa C Southey
  165. Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.

    • Agnes Jager
    • , John W M Martens
    • , Mieke Kriege
    • , Antoinette Hollestelle
    • , Caroline Seynaeve
    •  & Maartje J Hooning
  166. Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands.

    • Ans M Wvan den Ouweland
    •  & J Margriet Collée
  167. Department of Surgery and Cancer, Imperial College London, London, UK.

    • Robert Brown
    •  & James M Flanagan
  168. The Beatson West of Scotland Cancer Centre, Glasgow, UK.

    • James Paul
  169. Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.

    • Sara Margolin
  170. Department of Gynecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.

    • Nadeem Siddiqui
  171. Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.

    • Alice S Whittemore
    • , Valerie McGuire
    •  & Weiva Sieh
  172. Saarland Cancer Registry, Saarbrücken, Germany.

    • Christa Stegmaier
  173. Department of Environmental and Occupational Health, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada.

    • France Labrèche
  174. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.

    • Yu-Tang Gao
  175. Department of Medicine, McGill University, Montréal, Quebec, Canada.

    • Mark S Goldberg
  176. Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montréal, Quebec, Canada.

    • Mark S Goldberg
  177. Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

    • John R McLaughlin
  178. Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen–Nuremberg, Erlangen, Germany.

    • Arndt Hartmann
  179. Institute of Human Genetics, Friedrich Alexander University Erlangen–Nuremberg, Erlangen, Germany.

    • Arif B Ekici
  180. Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS INT, Milan, Italy.

    • Bernard Peissel
    • , Daniela Zaffaroni
    •  & Siranoush Manoukian
  181. Cogentech Cancer Genetic Test Laboratory, Milan, Italy.

    • Filomena Ficarazzi
    •  & Loris Bernard
  182. Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.

    • Monica Barile
    •  & Bernardo Bonanni
  183. Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California–Irvine, Irvine, California, USA.

    • Argyrios Ziogas
  184. Gynaecological Cancer Research Centre, University College London Elizabeth Garrett Anderson Institute for Women's Health, London, UK.

    • Aleksandra Gentry-Maharaj
    •  & Usha Menon
  185. Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr–Universität Bochum, Bochum, Germany.

    • Thomas Brüning
  186. Department of Internal Medicine, Evangelische Kliniken Bonn, Johanniter Krankenhaus, Bonn, Germany.

    • Yon-Dschun Ko
  187. Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland.

    • Jolanta Lissowska
  188. Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

    • Jolanta Kupryjanczyk
    • , Agnieszka Dansonka-Mieszkowska
    •  & Iwona K Rzepecka
  189. Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.

    • Arja Jukkola-Vuorinen
  190. Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

    • Mariusz Bidzinski
  191. Department of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland.

    • Saila Kauppila
  192. Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

    • Rob A E M Tollenaar
  193. Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.

    • Katarzyna Jaworska
  194. N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.

    • Natalia N Antonenkova
  195. Ministry of Public Health, Bangkok, Thailand.

    • Pornthep Siriwanarangsan
  196. Department of Gynecology and Obstetrics, Ludwig-Maximilians-Universität, Munich, Germany.

    • Nina Ditsch
  197. Insitute of Human Genetics, Technische Universität, Munich, Germany.

    • Peter Lichtner
  198. Department of Gynaecology and Obstetrics, Centre of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.

    • Rita K Schmutzler
    • , Kerstin Rhiem
    •  & Barbara Wappenschmidt
  199. Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany.

    • Rita K Schmutzler
    • , Kerstin Rhiem
    •  & Barbara Wappenschmidt
  200. Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

    • Hiroji Iwata
  201. Singapore Eye Research Institute, National University of Singapore, Singapore.

    • M Kamran Ikram
  202. Shanghai Center for Disease Control and Prevention, Shanghai, China.

    • Wei Lu
  203. Wexner Medical Center, Division of Oncology, The Ohio State University, Columbus, Ohio, USA.

    • Charles Shapiro
  204. Roswell Park Cancer Institute, Buffalo, New York, USA.

    • Foluso Ademuyiwa
  205. Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.

    • George Fountzilas
  206. Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan.

    • Jyh-Cherng Yu
  207. Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.

    • Ming-Feng Hou
  208. Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan.

    • Ming-Feng Hou
  209. Institut Curie, Department of Tumour Biology, Paris, France.

    • Dominique Stoppa-Lyonnet
    • , Bruno Buecher
    •  & Virginie Caux-Moncoutier
  210. Institut Curie, INSERM U830, Paris, France.

    • Dominique Stoppa-Lyonnet
  211. Université Paris Descartes, Sorbonne Paris Cité, Paris, France.

    • Dominique Stoppa-Lyonnet
  212. Basser Research Center, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

    • Timothy R Rebbeck
    • , Katherine L Nathanson
    •  & Susan M Domchek
  213. Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

    • Timothy R Rebbeck
  214. Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA.

    • Marion Piedmonte
  215. Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

    • Christian F Singer
    • , Daphne Gschwantler Kaulich
    •  & Muy-Kheng Tea
  216. The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel.

    • Eitan Friedman
    • , Shani Shimon Paluch
    •  & Yael Laitman
  217. Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel.

    • Eitan Friedman
    • , Shani Shimon Paluch
    •  & Yael Laitman
  218. Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.

    • Mads Thomassen
    •  & Torben A Kruse
  219. Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

    • Kenneth Offit
    •  & Mark Robson
  220. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

    • Thomas V O Hansen
  221. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.

    • Susan L Neuhausen
  222. Department of Biological Sciences, Center for Translational Cancer Research, University of Delaware, Newark, Delaware, USA.

    • Csilla I Szabo
  223. Genetic Counseling Unit, Hereditary Cancer Program, l'Institut d'Investigació Biomèdica de Bellvitge–Catalan Institute of Oncology, Barcelona, Spain.

    • Ignacio Blanco
  224. Center for Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

    • Judy Garber
  225. Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.

    • Steven A Narod
  226. Clinical Cancer Genetics, City of Hope, Duarte, California, USA.

    • Jeffrey N Weitzel
  227. Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS, Padua, Italy.

    • Marco Montagna
  228. Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.

    • Edith Olah
  229. Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

    • Andrew K Godwin
  230. Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece.

    • Drakoulis Yannoukakos
  231. Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

    • David E Goldgar
  232. Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.

    • David E Goldgar
  233. Molecular Oncology Laboratory, Hospital Clinico San Carlos, Madrid, Spain.

    • Trinidad Caldes
  234. N.N. Petrov Institute of Oncology, St. Petersburg, Russia.

    • Evgeny N Imyanitov
  235. Latvian Biomedical Research and Study Centre, Riga, Latvia.

    • Laima Tihomirova
  236. Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

    • Banu K Arun
  237. Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

    • Banu K Arun
  238. Victorian Breast Cancer Research Consortium Cancer Genetics Laboratory, Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.

    • Ian Campbell
  239. Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

    • Arjen R Mensenkamp
  240. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

    • Christi J van Asperen
  241. Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.

    • Kees E P van Roozendaal
  242. Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands.

    • Hanne Meijers-Heijboer
  243. Department of Genetics, University of Groningen, University Medical Center, Groningen, The Netherlands.

    • Jan C Oosterwijk
  244. Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.

    • Rob B van der Luijt
  245. Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands.

    • Theo A Mvan Os
  246. Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

    • D Gareth Evans
  247. Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.

    • Julian Barwell
  248. Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.

    • Lisa Walker
  249. Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James' Hospital, Dublin, Ireland.

    • M John Kennedy
  250. Laboratory Medicine at Southern General Hospital, Glasgow, UK.

    • Rosemarie Davidson
  251. West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK.

    • Trevor Cole
  252. INSERM U946, Fondation Jean Dausset, Paris, France.

    • Brigitte Bressac-de Paillerets
  253. Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France.

    • Brigitte Bressac-de Paillerets
  254. INSERM U1052, Centre National de Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France.

    • Francesca Damiola
    • , Olga M Sinilnikova
    •  & Sylvie Mazoyer
  255. Centre de Génétique, Centre Hôspitalier Universitaire Dijon, Université de Bourgogne, Dijon, France.

    • Laurence Faivre
  256. Centre Georges François Leclerc, Dijon, France.

    • Laurence Faivre
  257. Centre Antoine Lacassagne, Nice, France.

    • Marc Frenay
  258. Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Léon Bérard, Lyon, France.

    • Olga M Sinilnikova
    •  & Sophie Giraud
  259. Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France.

    • Olivier Caron
  260. Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.

    • Valérie Bonadona
  261. Université Lyon 1, CNRS UMR 5558, Lyon, France.

    • Valérie Bonadona
  262. Department of Molecular Medicine, Sapienza University, Rome, Italy.

    • Giuseppe Giannini
  263. Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy.

    • Loris Bernard
  264. Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy.

    • Riccardo Dolcetti
  265. Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein and University Kiel, Kiel, Germany.

    • Norbert Arnold
  266. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

    • Christoph Engel
  267. Department of Obstetrics and Gynecology, University Medical Center, Heinrich–Heine University, Düsseldorf, Germany.

    • Dieter Niederacher
  268. Institute of Human Genetics, University Hospital of Schleswig-Holstein, University Kiel, Kiel, Germany.

    • Hansjoerg Plendl
  269. Department of Human Genetics, University of Heidelberg, Heidelberg, Germany.

    • Christian Sutter
  270. Department of Oncology, Lund University, Lund, Sweden.

    • Åke Borg
  271. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.

    • Beatrice Melin
  272. Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.

    • Johanna Rantala
  273. Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund, Sweden.

    • Maria Soller
  274. Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Katherine L Nathanson
    •  & Susan M Domchek
  275. Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, Illinois, USA.

    • Gustavo C Rodriguez
  276. Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus, Ohio, USA.

    • Ritu Salani
  277. Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.

    • Anne-Bine Skytte
  278. Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.

    • Uffe Birk Jensen
  279. Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

    • Anne-Marie Gerdes
  280. Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

    • Bent Ejlertsen
  281. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

    • Lenka Foretova
  282. Pathology Queensland, The Royal Brisbane and Women's Hospital, Herston, Brisbane, Queensland, Australia.

    • Sunil R Lakhani
  283. Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.

    • Andrew Berchuck

Consortia

  1. Australian Cancer Study

    A list of members is provided in the Supplementary Note.

  2. Australian Ovarian Cancer Study

    A list of members is provided in the Supplementary Note.

  3. Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)

    A list of members is provided in the Supplementary Note.

  4. Gene Environment Interaction and Breast Cancer (GENICA)

    A list of members is provided in the Supplementary Note.

  5. Swedish Breast Cancer Study (SWE-BRCA)

    A list of members is provided in the Supplementary Note.

  6. The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)

    A list of members is provided in the Supplementary Note.

  7. Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE)

    A list of members is provided in the Supplementary Note.

  8. Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO)

    A list of members is provided in the Supplementary Note.

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