News & Views | Published:

The evolutionary biography of chronic lymphocytic leukemia

Nature Genetics volume 45, pages 229231 (2013) | Download Citation

A recent study shows that the life history of chronic lymphocytic leukemia is characterized by a complex and dynamic architecture involving the development of subclones with changing dominance over time. This innovative study provides a framework to design anticipation-based chemotherapy approaches for cancer treatment.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Am. Biol. Teach. 35, 125–129 (1973).

  2. 2.

    Science 194, 23–28 (1976).

  3. 3.

    et al. Nature 475, 101–105 (2011).

  4. 4.

    et al. N. Engl. J. Med. 365, 2497–2506 (2011).

  5. 5.

    et al. Nat. Genet. 44, 47–52 (2012).

  6. 6.

    et al. Blood 120, 4191–4196 (2012).

  7. 7.

    et al. Cell published online; doi:10.1016/j.cell.2013.01.019 (14 February 2013).

  8. 8.

    , , , & Nat. Rev. Cancer 10, 37–50 (2010).

  9. 9.

    & Nature 481, 306–313 (2012).

  10. 10.

    et al. Nat. Genet. 44, 1236–1242 (2012).

  11. 11.

    et al. Leukemia published online; doi:10.1038/leu.2012.268 (13 December 2012).

  12. 12.

    et al. Nature 481, 506–510 (2012).

  13. 13.

    et al. Cell 149, 994–1007 (2012).

  14. 14.

    et al. Nature 472, 90–94 (2012).

  15. 15.

    , & J. Clin. Invest. 122, 3432–3438 (2012).

Download references

Author information

Affiliations

  1. Xose S. Puente and Carlos López-Otín are in the Departamento de Bioquímica y Biología Molecular and the Instituto Universitario de Oncología (IUOPA) at the Universidad de Oviedo, Oviedo, Spain.

    • Xose S Puente
    •  & Carlos López-Otín

Authors

  1. Search for Xose S Puente in:

  2. Search for Carlos López-Otín in:

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Carlos López-Otín.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/ng.2556

Further reading Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing