A new study shows that alteration of poly(dA:dT) tracts in promoters offers a broadly applicable genetic mechanism for predictably tuning gene expression with high resolution. By systematically manipulating these tracts in a controlled yeast system, the authors demonstrate quantitative mechanistic relationships linking regulatory DNA sequences, nucleosome occupancy, transcription factor binding and gene expression.
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After agreeing to write this piece, J. Lieb was jointly awarded a grant with E. Segal.
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Palpant, T., Lieb, J. Tuning gene expression with nucleosome-disfavoring sequences. Nat Genet 44, 735–736 (2012). https://doi.org/10.1038/ng.2328
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DOI: https://doi.org/10.1038/ng.2328
