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Cell type–specific eQTLs in the human immune system

A new study reports the mapping of gene expression in primary immune cell subsets, showing the presence of cell type–specific cis and trans expression quantitative trait loci (eQTLs). The identification of cell type–specific trans-regulated networks can inform functional studies of susceptibility loci identified from genome-wide association studies for human complex diseases.

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Figure 1: A summary of the major cell subsets in the lymphoid (T-cell and B-cell) and myeloid (monocyte and dendritic) lineages.

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Correspondence to Peter K Gregersen.

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Gregersen, P. Cell type–specific eQTLs in the human immune system. Nat Genet 44, 478–480 (2012). https://doi.org/10.1038/ng.2258

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