Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12

Abstract

We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, 26 kb centromeric to the first known locus (rs4430796); these loci are separated by a recombination hot spot. We confirmed the association with a SNP in the second locus (rs11649743) in five additional populations, with P = 1.7 × 10−9 for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Schematic view of genetic association between SNPs at 17q12 and prostate cancer risk in two study populations.

References

  1. Gudmundsson, J. et al. Nat. Genet. 39, 977–983 (2007).

    Article  CAS  Google Scholar 

  2. Eeles, R.A. et al. Nat. Genet. 40, 316–321 (2008).

    Article  CAS  Google Scholar 

  3. Thomas, G. et al. Nat. Genet. 40, 310–315 (2008).

    Article  CAS  Google Scholar 

  4. Zheng, S.L. et al. N. Engl. J. Med. 358, 910–919 (2008).

    Article  CAS  Google Scholar 

  5. Sun, J. et al. Prostate 68, 691–697 (2008).

    Article  CAS  Google Scholar 

  6. Yeager, M. et al. Nat. Genet. 39, 645–649 (2007).

    Article  CAS  Google Scholar 

  7. Gudmundsson, J. et al. Nat. Genet. 39, 631–637 (2007).

    Article  CAS  Google Scholar 

  8. Haiman, C.A. et al. Nat. Genet. 39, 638–644 (2007).

    Article  CAS  Google Scholar 

  9. Zheng, S.L. et al. J. Natl. Cancer Inst. 99, 1525–1533 (2007).

    Article  CAS  Google Scholar 

  10. Amundadottir, L.T. et al. Nat. Genet. 38, 652–658 (2006).

    Article  CAS  Google Scholar 

  11. Freedman, M.L. et al. Proc. Natl. Acad. Sci. USA 103, 14068–14073 (2006).

    Article  CAS  Google Scholar 

  12. Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. Nat. Genet. 39, 906–913 (2007).

    Article  CAS  Google Scholar 

  13. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. Bioinformatics 21, 263–265 (2005).

    Article  CAS  Google Scholar 

  14. Gabriel, S.B. et al. Science 296, 2225–2229 (2002).

    Article  CAS  Google Scholar 

  15. Fearnhead, P. et al. Bioinformatics 22, 3061–3066 (2006).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank all the study subjects who participated in this study. We also thank the Regional Cancer Registries and the CAPS-steering committee, including E. Varenhorst. We acknowledge the support of W.T. Gerrard, M. Duhon, Jennifer and John Chalsty and D. Koch. We also thank the National Cancer Institute Cancer Genetic Markers of Susceptibility Initiative (CGEMS) for making the data available publicly. We take full responsibility for the study design, data collection, analysis and interpretation of the data, the decision to submit the manuscript for publication, and the writing of the manuscript. The study is supported by National Cancer Institute (CA106523, CA106523 and CA95052 to J.X., CA112517, CA58236 to W.B.I., CA86323 to A.W.P., Department of Defense grant PC051264 to J.X.), as well as support from Swedish Cancer Society (Cancerfonden) and Swedish Research Council to H.G.

Author information

Authors and Affiliations

Authors

Contributions

J.X., W.B.I., H.G., J.C., D.D. and J.M.T. designed and directed the study. S.L.Z. directed genotyping. Jielin Sun, F.W., F.-C.H., S.-T.K., Y.Z., L.D., Jishan Sun, J.L., B.-L.C. and J.X. conducted data analysis. S.D.I., K.E.W., B.J.T., A.W.P., P.C.W. and W.B.I. were involved in the sample collection at Johns Hopkins Hospital. P.S., H.-O.A., J.A., J.-E.J. and H.G. were involved in the sample collection in Sweden. L.D.P., Z.G., W.L. and T.L. performed laboratory analyses. A.R.T. and T.S.A. provided administrative and technical support for the study.

Corresponding authors

Correspondence to Henrik Grönberg or William B Isaacs.

Supplementary information

Supplementary Text and Figures

Supplementary Methods, Supplementary Tables 1–6, Supplementary Figure 1 (PDF 1008 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Sun, J., Zheng, S., Wiklund, F. et al. Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12. Nat Genet 40, 1153–1155 (2008). https://doi.org/10.1038/ng.214

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.214

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing