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Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Nature Genetics volume 40, pages 952–954 (2008)Cite this article

Abstract

To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.

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Figure 1: Genome-wide quantitative trait transcripts analysis of cis eQTLs in the kidney with blood pressure.
Figure 2: Arterial blood pressure and renal expression of wild-type Cd36.

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Acknowledgements

The authors acknowledge funding support to T.W.K. from the US National Institutes of Health, to L.K. and O.V. from the Ministry of Health of the Czech Republic, to M.P., N.H. and T.J.A. from the European Commission within the Sixth Framework Programme through the Integrated Project EURATools, to M.P. from the Grant Agency of the Academy of Sciences of the Czech Republic, to M.P. and V.K. from Ministry of Education of the Czech Republic, and to N.H. from the German Ministry for Science and Education (National Genome Research Network). M.P. is an International Research Scholar of the Howard Hughes Medical Institute. E.P. is a Research Councils UK Fellow.

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Author notes

  1. Paul C Churchill: Deceased.

Authors and Affiliations

  1. Institute of Physiology and Center for Applied Genomics, Academy of Sciences of the Czech Republic, Prague, 14220, Czech Republic

    Michal Pravenec, Vaclav Zidek, Vladimir Landa, Vladimir Kren & Petr Mlejnek

  2. Institute of Biology and Medical Genetics, First Medical Faculty and General Teaching Hospital, Charles University, Prague, 12800, Czech Republic

    Michal Pravenec & Vladimir Kren

  3. Department of Physiology, Wayne State University School of Medicine, Detroit, 48201, Michigan, USA

    Paul C Churchill, Monique C Churchill & Joseph Dunbar

  4. Institute for Clinical and Experimental Medicine, Prague, 14021, Czech Republic

    Ondrej Viklicky, Ludmila Kazdova & Martina Maxova

  5. MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, W12 ONN, UK

    Timothy J Aitman, Enrico Petretto & Caroline A Wallace

  6. Division of Epidemiology, Public Health and Primary Care, Faculty of Medicine, Imperial College, London, W12 ONN, UK

    Enrico Petretto

  7. Max Delbruck Center for Molecular Medicine, Berlin-Buch, 13125, Germany

    Norbert Hubner & Heike Zimdahl

  8. Department of Internal Medicine, Loyola University and Hines VA Hospital, Maywood, 60153, Illinois, USA

    Anil Bidani & Karen Griffin

  9. Department of Medicine, University of Michigan Medical School, Ann Arbor, 48109, Michigan, USA

    Nathan Qi

  10. Department of Laboratory Medicine, University of California, San Francisco, 94107, California, USA

    Jiaming Wang & Theodore W Kurtz

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  1. Michal Pravenec
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  12. Vladimir Landa
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  16. Nathan Qi
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  18. Vladimir Kren
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Corresponding author

Correspondence to Theodore W Kurtz.

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Supplementary Text and Figures

Supplementary Methods, Supplementary Figures 1 and 2, Supplementary Tables 1 and 2 (PDF 24 kb)

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Pravenec, M., Churchill, P., Churchill, M. et al. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet 40, 952–954 (2008). https://doi.org/10.1038/ng.164

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