Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension

Abstract

To identify renally expressed genes that influence risk for hypertension, we integrated expression quantitative trait locus (QTL) analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy, together with renal transplantation studies in SHR progenitor, transgenic and congenic strains, identified deficient renal expression of Cd36 encoding fatty acid translocase as a genetically determined risk factor for spontaneous hypertension.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Genome-wide quantitative trait transcripts analysis of cis eQTLs in the kidney with blood pressure.
Figure 2: Arterial blood pressure and renal expression of wild-type Cd36.

References

  1. Lifton, R.P. Harvey Lect. 100, 71–101 (2004).

    PubMed  Google Scholar 

  2. Hubner, N. et al. Nat. Genet. 37, 243–253 (2005).

    Article  CAS  PubMed  Google Scholar 

  3. Passador-Gurgel, G., Hsieh, W.P., Hunt, P., Deighton, N. & Gibson, G. Nat. Genet. 39, 264–268 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. Aitman, T.J. et al. Nat. Genet. 21, 76–83 (1999).

    Article  CAS  PubMed  Google Scholar 

  5. Pravenec, M. et al. J. Clin. Invest. 103, 1651–1657 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Pravenec, M. et al. Nat. Genet. 27, 156–158 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Pravenec, M. et al. Physiol. Res. 52, 681–688 (2003).

    CAS  PubMed  Google Scholar 

  8. Koonen, D.P. et al. Circulation 116, 2139–2147 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Glazier, A.M., Nadeau, J.H. & Aitman, T.J. Science 298, 2345–2349 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Hirano, K. et al. Trends Cardiovasc. Med. 13, 136–141 (2003).

    Article  CAS  PubMed  Google Scholar 

  11. Miyaoka, K. et al. Lancet 357, 686–687 (2001).

    Article  CAS  PubMed  Google Scholar 

  12. Bordessoule, D., Jones, M., Gatter, K.C. & Mason, D.Y. Br. J. Haematol. 83, 370–383 (1993).

    Article  CAS  PubMed  Google Scholar 

  13. Kincer, J.F. et al. J. Biol. Chem. 277, 23525–23533 (2002).

    Article  CAS  PubMed  Google Scholar 

  14. Zhu, W. & Smart, E.J. J. Biol. Chem. 280, 29543–29550 (2005).

    Article  CAS  PubMed  Google Scholar 

  15. Zou, A.P. & Cowley, A.W., Jr. Curr. Hypertens. Rep. 1, 178–186 (1999).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors acknowledge funding support to T.W.K. from the US National Institutes of Health, to L.K. and O.V. from the Ministry of Health of the Czech Republic, to M.P., N.H. and T.J.A. from the European Commission within the Sixth Framework Programme through the Integrated Project EURATools, to M.P. from the Grant Agency of the Academy of Sciences of the Czech Republic, to M.P. and V.K. from Ministry of Education of the Czech Republic, and to N.H. from the German Ministry for Science and Education (National Genome Research Network). M.P. is an International Research Scholar of the Howard Hughes Medical Institute. E.P. is a Research Councils UK Fellow.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Theodore W Kurtz.

Supplementary information

Supplementary Text and Figures

Supplementary Methods, Supplementary Figures 1 and 2, Supplementary Tables 1 and 2 (PDF 24 kb)

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pravenec, M., Churchill, P., Churchill, M. et al. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet 40, 952–954 (2008). https://doi.org/10.1038/ng.164

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ng.164

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing