The combination of genomic, epidemiological and evolutionary analyses provides a powerful toolbox for understanding how pathogens adapt to their human hosts. By sequencing 112 Burkholderia dolosa genomes from an outbreak among patients with cystic fibrosis, a new study documents evolution in action and identifies a set of genes that contributed to the pathogen's adaptation.
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Lenski, R. Chance and necessity in the evolution of a bacterial pathogen. Nat Genet 43, 1174–1176 (2011). https://doi.org/10.1038/ng.1011