Abstract
Adenylyl-(3′–5′-adenylyl-(3′–5′)-adenosine, ApApA, crystallised from acidic, aqueous solution as a zwitterion, Ap−A+p−A+. The molecule consists of both a helical section, Ap−A+, and a non-helical section, A+p−A+; two anti-parallel molecules are linked by base pairing between protonated adenines. Although the base pair scheme is as proposed for poly(A+).poly(A+), the ApA+pA+ duplex is not double helical.
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SUCK, D., MANOR, P., GERMAIN, G. et al. X-ray Study of Helix, Loop and Base Pair Stacking in Trinucleoside Diphosphate ApApA. Nature New Biology 246, 161–165 (1973). https://doi.org/10.1038/newbio246161a0
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DOI: https://doi.org/10.1038/newbio246161a0
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