Abstract
INGESTION of the shrub Solanum malacoxylon Sendtner (syn Solanum glaucum Dun) produces a rapid hypercalcaemia, and hyperphosphataemia1, 2 which can result in a general calcinosis in various animals3–7. The effects seem to be due to a large increase in calcium absorption from the diet8, and the condition resembles that of vitamin D'intoxication9. Smith and O'Donell9 showed that oral administration of dried, milled, S. nialacoxylon leaves, 72 and 48 h earlier, produces effects similar to those of cholecalciferol (vitamin D3) on in vitro intestinal calcium absorption in rats. They mention that, although the effects on calcium absorption closely resemble those of cholecalciferol, contrary to what one might expect if the active principle were vitamin D, the activity is soluble in water3.
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References
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HUMPHREYS, D. Studies on the Active Principle of Solanum malacoxylon. Nature New Biology 246, 155–157 (1973). https://doi.org/10.1038/newbio246155a0
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DOI: https://doi.org/10.1038/newbio246155a0
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