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Antiviral and Non-antiviral Activity of Highly Purified Interferon

Nature New Biology volume 246, pages 141–143 (1973)Cite this article

Abstract

EVIDENCE has accumulated that interferons exert effects on cells other than causing them to become resistant to viruses. In addition to inducing antiviral, and antimicrobial1, activities, interferon preparations of various degrees of purity have been shown to inhibit cell growth2–11, facilitate interferon induction by ‘priming’12–15, suppress interferon production by ‘blocking’14, 16, 17, enhance phagocytic activity18, 19, enhance lysis of target cells by lymphocytes20, and enhance the susceptibility of cells to the toxicity of doukie-stranded RNAs (dsRNA)21–23. Comparisons of antiviral and these non-antiviral activity titres of interferon preparations have usually shown a strict correlation of antiviral and non-anti-viral activities regardless of the degree of purification8, 13, 14, 17, 21, suggesting that activities are attributable to interferon itself.

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Authors and Affiliations

  1. Department of Virology, Rega Institute for Medical Research, University of Leuven, Leuven

    WILLIAM B. STEWART II, ERIK De CLERCQ & PIERRE De SOMER

  2. Department of Microbiology, Medical College of Pennsylvania and Hospital, Philadelphia, Pennsylvania

    KURT BERG, CLIFTON A. OGBURN & KURT PAUCKER

Authors
  1. WILLIAM B. STEWART II
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  2. ERIK De CLERCQ
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  3. PIERRE De SOMER
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  4. KURT BERG
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  5. CLIFTON A. OGBURN
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  6. KURT PAUCKER
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STEWART II, W., De CLERCQ, E., De SOMER, P. et al. Antiviral and Non-antiviral Activity of Highly Purified Interferon. Nature New Biology 246, 141–143 (1973). https://doi.org/10.1038/newbio246141a0

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