Abstract
RECENTLY we reported that extracts of diploid human fibroblasts or of the used medium from the cultivation of these cells in vitro contained materials weighing between 30,000 and 50,000 daltons which would specifically inhibit the uptake of tritiated thymidine by WI-38 diploid human fibroblasts in vitro1. This specific and endogenous mitotic inhibitor was termed a fibroblast ‘chalone’, following the proposals of Bullough and Laurence2, 3.
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References
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HOUCK, J., SHARMA, V., RICHARD, S. et al. Fibroblast Chalone and Serum Mitogen (Anti-chalone). Nature New Biology 246, 111–113 (1973). https://doi.org/10.1038/newbio246111a0
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DOI: https://doi.org/10.1038/newbio246111a0
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