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Stimulation of DNA Synthesis in CNS Neurones by Sustained Depolarisation

Nature New Biology volume 246, pages 110–111 (1973)Cite this article

Abstract

IT has been proposed1, 2 that intracellular ionic concentration levels associated with the electrical transmembrane potential (Em) of somatic cells may be functionally involved in mitogenesis control, cells possessing a low Em level (−10 to −20 mV) being mitogenically active. This hypothesis has been supported by subsequent demonstrations that imposed intracellular ionic conditions simulating high Em levels effectively but reversibly block mitogenesis3, 4. As a corollary of this hypothesis, it was suggested2 that mitogenesis might be activated in highly polarised non-dividing cells (such as mature CNS neurones and muscle) by maintaining them in a sufficiently depolarised state. We have investigated this possibility for the case of chick spinal cord neurones depolarised with the cardiac glycoside ouabain.

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Authors and Affiliations

  1. Department of Biology, Old Dominion University, Norfolk, Virginia

    E. F. STILLWELL

  2. Laboratory of Cell and Molecular Biology, Eastern Virginia Medical School, Langley Research Center, Hampton, Virginia

    C. M. CONE & C. D. CONE JUN.

Authors
  1. E. F. STILLWELL
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  2. C. M. CONE
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  3. C. D. CONE JUN.
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STILLWELL, E., CONE, C. & CONE, C. Stimulation of DNA Synthesis in CNS Neurones by Sustained Depolarisation. Nature New Biology 246, 110–111 (1973). https://doi.org/10.1038/newbio246110a0

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