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An Antenatal Diagnosis of Spina Bifida in the Lewis Rat

Nature New Biology volume 246, pages 89–90 (1973)Cite this article

Abstract

ANTENATAL diagnosis from a cytogenetic and biochemical point of view of various genetic disorders is becoming possible through the study of cultured amniotic fluid cells. These procedures are becoming more established in the counselling of high risk families. The techniques have not, however, been expanded to include the diagnosis of certain closure malformations of the central nervous system such as spina bifida. These closure defects have not yet been associated with any recognisable biochemical or chromosomal abnormalities.

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References

  1. Brock, D. J. H., and Sutcliffe, R. G., Lancet, ii, 197 (1972).

  2. Emery, A. E. H., Eccleston, D., Scrimgeour, J. B., and Johnstone, M., J. Obstet. Gynaec. Br. Commonw., 79, 154 (1961).

    Article  Google Scholar 

  3. Clausen, J., Proc. Soc. exp. Biol. Med., 107, 170 (1961).

    Article  CAS  Google Scholar 

  4. Heitmann, R., and Uhlenbruck, G., Dt. Z. NervHeilk., 188, 187 (1966).

    CAS  Google Scholar 

  5. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  6. Immunoelectrophoretic Analysis (edit, by Grabar, P., and Burtin, P.) (Elsevier, New York, 1964).

  7. Ouchterlony, O., Prog. Allergy, 5, 1 (1958).

    CAS  PubMed  Google Scholar 

  8. Ceska, M., and Linden, A.-M., Immunology, 20, 123 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Animal Research Laboratory, Department of Anatomy, Downstate Medical Center, Brooklyn, New York, 11203

    J. N. MACRI

  2. Department of Anatomy, Downstate Medical Center, Brooklyn, New York, 11203

    M. S. JOSHI

  3. Animal Research Laboratory, Nassau County Medical Center, East Meadow, New York, 11554

    M. I. EVANS

Authors
  1. J. N. MACRI
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  2. M. S. JOSHI
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  3. M. I. EVANS
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MACRI, J., JOSHI, M. & EVANS, M. An Antenatal Diagnosis of Spina Bifida in the Lewis Rat. Nature New Biology 246, 89–90 (1973). https://doi.org/10.1038/newbio246089a0

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  • DOI: https://doi.org/10.1038/newbio246089a0

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