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Immunofluorescent Antigen associated with Epstein-Barr Virus induced by 5-Iododeoxyuridine

Nature New Biology volume 246, pages 72–73 (1973)Cite this article

Abstract

SEVERAL recent reports have described that a repressed Epstein-Barr virus (EBV) genome is indeed activated by treatment with thymidine analogues1–7. Our previous findings have indicated that the three different EBV-related immunofluorescent antigens, membrane antigens (MA)8, early antigens (EA)9 and viral capsid antigens (VCA)10, were all induced in both producer and non-producer human lymphoblastoid cell lines by 5-bromodeoxyuridine (BUdR) and 5-iododeoxyuridine3, 7, 11, 12. In these investigations, we frequently encountered a weak but distinct fluorescence appearing in the nucleus of nearly all cells after exposure to IUdR. The staining characteristics seemed to be quite different from those of MA, EA and VCA. Here we report that the particular fluorescence is obvious 1 d after exposure to IUdR and is closely related to EBV although distinct from the three immunofluorescent antigens known so far13.

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Authors and Affiliations

  1. Department of Virology, Cancer Institute, Hokkaido University, School of Medicine, Sapporo, N15 W7

    KENJI SUGAWARA & TOYORO OSATO

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  1. KENJI SUGAWARA
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  2. TOYORO OSATO
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SUGAWARA, K., OSATO, T. Immunofluorescent Antigen associated with Epstein-Barr Virus induced by 5-Iododeoxyuridine. Nature New Biology 246, 72–73 (1973). https://doi.org/10.1038/newbio246072a0

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  • DOI: https://doi.org/10.1038/newbio246072a0

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