Abstract
ONE of the basic problems of immunology is the distinction between self and non-self1. The mechanism of self non-reactivity (self tolerance) is not yet known in detail, but since unimpaired self reactive B cells have been detected in several circumstances it now seems that self tolerance is essentially a property of T cells2–4. An understanding of the mechanism by which virgin T cells discriminate between immunity (to non-self) and tolerance (to self) is thus the key to understanding self tolerance.
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(reprints): Department of Serology and Bacteriology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29.
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KONTIANEN, S., FELDMANN, M. Induction of Specific Helper Cells in vitro. Nature New Biology 245, 285–286 (1973). https://doi.org/10.1038/newbio245285a0
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DOI: https://doi.org/10.1038/newbio245285a0
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