Abstract
CASPERSSON'S discovery1 of the differential fluorescence of chromosomes stained in situ with acridine dyes has made two fundamental contributions to cytogenetics. First, individual chromosomes and even parts of chromosomes can now be accurately identified2. Second, the technique has opened new avenues of research into the structure and organisation of chromosomes3.
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Change history
01 March 1974
An Erratum to this paper has been published: https://doi.org/10.1038/248089d0
References
Caspersson, T., Zech, L., Modest, E. J., Foley, G. E., Wagh, U., and Simonsson, E., Expl Cell Res., 58, 128 (1969).
Conf. Standardiz. Hum. Cytogenet. Paris, 1971, Birth Defects (Original Articles Series), 8, 7, (The National Foundation, New York, 1972).
Hsu, T. C., A. Rev. Genet, (in the press).
Weisblum, B., and de Haseth, P. L., Proc. natn. Acad. Sci. U.S.A., 69, 629 (1972).
Pachmann, U., and Rigler, R., Expl Cell Res., 72, 602 (1972).
Michelson, A. M., Monny, C., and Kovoor, A., Biochimie, 54, 1129 (1972).
Sciander, R.-K., Biochem. J., 131, 749 (1973).
Ellison, J. R., and Barr, H. J., Chromosoma, 36, 375 (1972).
Pardue, M. L., and Gall, J. G., Science, N.Y., 168, 1356 (1970).
Jones, K. W., Nature, 225, 912, (1970).
Corneo, G., Ginelli, E., Soave, C., and Bernardi, G., Biochemistry, N.Y., 7, 4373 (1968).
Jones, K. W., and Corneo, G., Nature new Biol., 233, 268 (1971).
Corneo, G., Ginelli, E., and Polli, E., J. molec. Biol., 48, 319 (1970).
Caspersson, T., Zech, L., Johansson, C., and Modest, E. J., Chromosoma, 30, 215 (1970).
Comings, D. E., Avelino, E., Okada, T. A., and Wyandt, H. E., Expl Cell Res., 77, 469 (1973).
Seabright, M., Lancet, ii, 971 (1971).
de la Chapelle, A., Schröder, J., and Selander, R.-K., Hereditas, 69, 149 (1971).
de la Chapelle, A., Schröder, J., and Selander, R.-K., Chromosoma, 40, 347 (1973).
de la Chapelle, A., Schröder, J., and Selander, R.-K., and Stenstrand, K., Chromosoma, 42, 365 (1973).
Selander, R.-K., and de la Chapelle, A., Biochem. J., 131, 757 (1973).
Weisblum, B., and de Haseth, P. L., Chromosomes Today (in the press}.
Millar, D. B. S., and Steiner, R. F., Biochim. biophys. Acta, 102, 571 (1965).
Bernardi, G., in Methods of Enzymology (edit, by Grossman, L., and Moldave, K.), 21D, 124, (Academic Press, New York, 1971).
Miyazawa, Y., and Thomas, C. A., jun., J. molec. Biol., 11, 223 (1965).
Marmur, J., J. molec. Biol, 3, 208 (1961).
Kurnick, N. B., and Radcliffe, I. E., J. Lab. clin. Med., 60, 669 (1962).
Lerman, L. S., Proc. nat. Acad. Sci. U.S.A., 49, 94 (1963).
Allison, J. L., O'Brien, R. L., and Hahn, F. E., Science, N. Y., 149, 1111 (1965).
Cohen, S. N., and Yielding, K. L., J. biol. Chem., 240, 3123, (1965).
Ward, D. C., Reich, E., and Goldberg, I. H., Science, N.Y., 149, 1259 (1965).
Britten, R. J., and Kohne, D. E., Science, N.Y., 161, 529 (1968).
Saunders, G. F., Shirakawa, S., Saunders, P. P., Arrighi, F. E., and Hsu, T. C., J. molec. Biol., 63, 323 (1972).
Dev, V. G., Warburton, D., Miller, O. J., Miller, D. A., Erlanger, B. F., and Beiser, S. M., Expl Cell Res., 74, 288 (1972).
Schreck, R. R., Warburton, D., Miller, O. J., Beiser, S. M., and Erlanger, B. F., Proc. natn. Acad. Sci. U.S.A., 70, 804 (1973).
Kleinwächter, V., Balcarovà, Z., and Boh´cek, J., Biochim. biophys. Acta, 174, 188 (1969).
Ramstein, J., and Leng, M., Biochim. biophys. Acta, 281, 18 (1972).
Stocken, J. C., and Lisanti, J. A., Chromosoma, 37, 117 (1972).
Mace, M. L., jun., Tevethia, S. S., and Brinkley, B. R., Expl Cell Res., 75, 521 (1972).
Ris, H., in Handbook of Molecular Cytology (edit, by Lima-de-Faria, A.), 222 (North-Holland, Amsterdam, 1969).
Nash, D., and Plaut, W., Proc. nat. Acad. Sci. U.S.A., 51, 731 (1964).
Nature, 243, 55 (1973).
Clark, R. J., and Felsenfeld, G., Nature new Biol., 240, 226 (1972).
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SELANDER, RK., DE LA CHAPELLE, A. The Fluorescence of Quinacrine Mustard with Nucleic Acids. Nature New Biology 245, 240–244 (1973). https://doi.org/10.1038/newbio245240a0
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DOI: https://doi.org/10.1038/newbio245240a0
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