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Discontinuous Elongation of Both Strands at the Replication Forks in Polyoma DNA Replication

Nature New Biology volume 245, pages 203–205 (1973)Cite this article

Abstract

THE replication of the double stranded circular DNA of the closely related polyoma and SV40 viruses proceeds by the formation of replicative intermediates consisting of newly formed linear daughter strands hydrogen bonded to co-valently closed parent strands1–3. Replication of SV40 DNA starts at a unique origin4,5, is bidirectional6,7 and is terminated at about 180° from the origin. We assume that polyoma DNA is replicated in a similar fashion and the conclusion arrived at in this article depends on this assumption.

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Authors and Affiliations

  1. Medical Nobel Institute, Department of Biochemistry, Karolinska Institute, 104 01, Stockholm

    VINCENT PIGIET, ERNST L. WINNACKER, ROLF ELIASSON & PETER REICHARD

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  1. VINCENT PIGIET
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  2. ERNST L. WINNACKER
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  3. ROLF ELIASSON
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  4. PETER REICHARD
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PIGIET, V., WINNACKER, E., ELIASSON, R. et al. Discontinuous Elongation of Both Strands at the Replication Forks in Polyoma DNA Replication. Nature New Biology 245, 203–205 (1973). https://doi.org/10.1038/newbio245203a0

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