Abstract
THE development of somatic hybrids between human and mouse cells has resulted in a considerable advance in the analysis of human somatic cells. Gene linkage relationships1,2 and the assignment of genes to human chromosomes3 have been established by enzymatic and cytogenetic analyses of hybrid cells. One of the most interesting and valuable features of somatic hybrids between mouse and human cells is the preferential loss of human chromosomes, in an essentially random manner, from the hybrid4. Using this property, it was shown that the thymidine kinase (TK) gene is on a human E group chromosome4,5. This finding was confirmed and the chromosome identified as E17 (refs 6 and 7).
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MCDOUGALL, J., KUCHERLAPATI, R. & RUDDLE, F. Localization and Induction of the Human Thymidine Kinase Gene by Adenovirus 12. Nature New Biology 245, 172–175 (1973). https://doi.org/10.1038/newbio245172a0
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DOI: https://doi.org/10.1038/newbio245172a0
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