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Effect of Ouabain on the Current underlying Spontaneous Diastolic Depolarization in Cardiac Purkinje Fibres

Nature New Biology volume 245, pages 118–120 (1973)Cite this article

Abstract

CARDIAC glycosides are important in the treatment of heart failure, but the therapeutic positive inotropic effect of these glycosides is complicated by their tendency to cause arrhythmias1,2. The mechanism by which cardiac glycosides induce arrhythmias may be related to an effect on the ionic current which underlies spontaneous diastolic depolarization in cardiac Purkinje fibres. To determine the effects of cardiac glycosides on this ionic current we studied the effects of ouabain using a voltage clamp technique.

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Authors and Affiliations

  1. Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, N.Y., 10032

    R. S. ARONSON, J. M. GELLES & B. F. HOFFMAN

Authors
  1. R. S. ARONSON
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  2. J. M. GELLES
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  3. B. F. HOFFMAN
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ARONSON, R., GELLES, J. & HOFFMAN, B. Effect of Ouabain on the Current underlying Spontaneous Diastolic Depolarization in Cardiac Purkinje Fibres. Nature New Biology 245, 118–120 (1973). https://doi.org/10.1038/newbio245118a0

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  • DOI: https://doi.org/10.1038/newbio245118a0

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