Abstract
PARATHYROID hormone (PTH) and prostaglandin E1 (PGE1 may operate by the same or similar mechanisms to produce in vitro osteolysis1, which depends on the release of destructive lysosomal enzymes by bone cells2. Aspirin has been reported to inhibit the release of enzymes from lysosomes in vitro3 and we therefore tested its ability to inhibit osteolysis stimulated by PTH and PGE1 in vitro.
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POWLES, T., EASTY, D., EASTY, G. et al. Aspirin Inhibition of in vitro Osteolysis stimulated by Parathyroid Hormone and PGE1. Nature New Biology 245, 83–84 (1973). https://doi.org/10.1038/newbio245083a0
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DOI: https://doi.org/10.1038/newbio245083a0
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