Abstract
A FUNCTIONALLY defective molecule, immunologically similar to Factor VIII, has been found in haemophilia A patients in concentrations similar to normal, but in von Willebrand's disease the immunological concentration of Factor VIII is reduced or absent1,2. Two principal approaches have been used to detect this cross-reactive material (CRM). One method is based on the ability of plasma incubated with antibody to neutralize the anticoagulant effect of the antibody (antibody neutralization). The second group of methods involves the use of immunoprecipitation techniques.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bennett, E., and Huehns, E. R., Lancet, ii, 956 (1970).
Zimmerman, T. S., Ratnoff, O. D., and Powell, A. E., J. clin. Invest., 50, 244 (1971).
Hoyer, L., and Breckenridge, R. T., Blood, 32, 962 (1968).
Feinstein, D., Chong, M. N. Y., Kasper, C. K., and Rapaport, S. E., Science, N. Y., 163, 1071 (1969).
Denson, K. W. E., Biggs, R., Haddon, M. E., Barret, R., and Cabb, K., Br. J. Haematol., 17, 163 (1969).
Meyer, D., Lavergne, J. M., Larrieu, M. J., and Josso, F., Thromb. Res., 1, 183 (1972).
Gralnick, H. R., Abrell, E., and Bagley, J., Nature new Biol., 230, 16 (1971).
Stites, D. P., Hershgold, E. J., Perlman, J. S., and Fudenberg, H. H., Science, N.Y., 171, 196 (1971).
Marchesi, S. L., Shulman, N. R., and Gralnick, H. R., J. clin. Invest., 51, 2151 (1972).
Hoyer, L., Blood, 39, 481 (1972).
Owen, W. G., and Wagner, R. H., Thromb. Diath. haemorrh., 27, 502 (1972).
Bouma, B. N., Wiegernick, Y., Sixma, J. J., van Mourik, J. A., and Mochtar, I. A., Nature new Biol., 236, 104 (1972).
Weiss, H. J., Rogers, J., and Brand, H., Prog. Am. Soc. Hematol. Fifteenth Annual Meeting, Hollywood, Florida, 47 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GRALNICK, H., COLLER, B. & MARCHESI, S. Immunological Studies of Factor VIII in Haemophilia and von Willebrand's Disease. Nature New Biology 244, 281–282 (1973). https://doi.org/10.1038/newbio244281a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/newbio244281a0
