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Altered Metabolism and Endogenous Cyclic AMP in Cultured Cells deficient in Cyclic AMP-binding Proteins

Nature New Biology volume 244, pages 167–169 (1973)Cite this article

Abstract

IT is generally supposed that protein kinases, activated by cyclic AMP, mediate the diverse biological activities of the nucleotide1–3. The evidence for this assumption derives largely from experiments dealing with regulation of the activity of enzymes concerned with glycogen metabolism4,5. We have recently reported the selection of a population of mouse lymphoma cells deficient in both the cyclic AMP-dependent histone Phosphokinase activity and in the binding of cyclic AMP to the enzyme's regulatory subunit6.

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Authors and Affiliations

  1. Departments of Biochemistry and Biophysics, Medicine and Pharmacology, University of California, San Francisco, California, 94122

    VIOLET DANTEL, HENRY R. BOURNE & GORDON M. TOMKINS

  2. Weizmann Institute of Science, Rehovot, Israel

    VIOLET DANTEL

Authors
  1. VIOLET DANTEL
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  2. HENRY R. BOURNE
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  3. GORDON M. TOMKINS
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DANTEL, V., BOURNE, H. & TOMKINS, G. Altered Metabolism and Endogenous Cyclic AMP in Cultured Cells deficient in Cyclic AMP-binding Proteins. Nature New Biology 244, 167–169 (1973). https://doi.org/10.1038/newbio244167a0

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  • DOI: https://doi.org/10.1038/newbio244167a0

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