Abstract
THE newly synthesized nucleoside analogue virazole (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) belongs to the class of nucleosides of pyrazomycin and showdomycin with a five-membered heterocyclic base linked to a β-D-ribofuranose moiety1. Virazole is of considerable interest because it is the first synthetic nucleoside that shows broad-spectrum antiviral properties. The chemical characterization and biological properties of virazole have been described recently2–7. The purpose of our X-ray study was to establish unequivocally its chemical structure and conformation and to investigate its mode of action.
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PRUSINER, P., SUNDARALINGAM, M. A New Class of Synthetic Nucleoside Analogues with Broad-spectrum Antiviral Properties. Nature New Biology 244, 116–118 (1973). https://doi.org/10.1038/newbio244116a0
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DOI: https://doi.org/10.1038/newbio244116a0
