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Similar Growth of Chinese Hamster Cells in the Presence of Phenethyl Alcohol or Dibutyryl Cyclic AMP

Nature New Biology volume 244, pages 84–86 (1973)Cite this article

Abstract

A great deal of evidence supports the view that cyclic AMP may be an important regulator of growth in mammalian cells and that a defect in cyclic AMP metabolism could explain some of the abnormal growth characteristics of cells transformed by oncogenic viruses1. Many reports suggest that transformed fibroblasts growing in the presence of cyclic AMP show morphological characteristics of untransformed cells2–5. These reports suggest that cyclic AMP restores “contact-inhibited growth” to malignant cultures4. Furthermore, measurements of proliferating 3T3 cells have indicated that these cells contain less cyclic AMP than resting 3T3 cells5. Also, levels of cyclic AMP in untransformed and transformed cells are inversely proportional to their doubling time5,6. An increase in cyclic AMP levels may be the signal for inhibition of growth.

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Authors and Affiliations

  1. Department of Microbiology, The University of Manitoba, Winnipeg, Manitoba, R3T 2N2

    J. A. WRIGHT, H. CERI & W. H. LEWIS

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  1. J. A. WRIGHT
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  2. H. CERI
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  3. W. H. LEWIS
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WRIGHT, J., CERI, H. & LEWIS, W. Similar Growth of Chinese Hamster Cells in the Presence of Phenethyl Alcohol or Dibutyryl Cyclic AMP. Nature New Biology 244, 84–86 (1973). https://doi.org/10.1038/newbio244084a0

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