Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Induction of Steroidogenesis in Tissue Culture by Cholera Enterotoxin

Nature New Biology volume 243, pages 246–247 (1973)Cite this article

Abstract

THE diarrhoea associated with natural cholera infection is thought to be caused by an enterotoxin produced by the cholera bacillus. Application of cell-free culture filtrates of Vibrio cholerae or its purified enterotoxin to ligatured loops of rabbit ileum or to human ileal mucosa is associated with stimulation of mucosal adenyl cyclase activity, increase of intracellular cyclic AMP, and exudation of water and electrolytes into the intestinal lumen1–3. The mechanisms involved are, however, unknown.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Field, M., Fromm, D., Wallace, K., and Greenough, W. B., J. Clin. Invest., 48, 24a (1969).

    Google Scholar 

  2. Al Awgati, Q., Cameron, J. L., Field, M., and Greenough, W. B., J. Clin. Invest., 49, 2a (1970).

    Google Scholar 

  3. Kimberg, D. V., Field, M., Johnson, J., Henderson, A., and Gershon, E., J. Clin. Invest., 50, 1218 (1971).

    Article  CAS  Google Scholar 

  4. Vaughan, M., Pierce, N. F., and Greenough, W. B., Nature, 226, 658 (1970).

    Article  CAS  Google Scholar 

  5. Graybill, J. R., Kaplan, M. M., and Pierce, N. F., Clin. Res., 18, 454 (1970).

    Google Scholar 

  6. Lief, P. D., and Keusch, G. T., Infection and Immunity, 5, 634 (1971).

    Google Scholar 

  7. Craig, J. P., Nature, 207, 614 (1965).

    Article  CAS  Google Scholar 

  8. Finkelstein, R. A., Infection and Immunity, 1, 464 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Yasumura, Y., Buonassisi, V., and Sato, G., Cancer Res., 26, 529 (1966).

    CAS  PubMed  Google Scholar 

  10. Yasumura, Y., Amer. Zoologist, 8, 285 (1968).

    Article  CAS  Google Scholar 

  11. Finkelstein, R. A., and Spalluto, J. J., J. Infect. Dis., 121, S63(1970).

    Article  CAS  Google Scholar 

  12. Schimmer, B. P., J. Cell. Physiol., 74, 115 (1969).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Iowa and Iowa City Veterans Administration Hospital, Iowa City, Iowa, 52240

    SAM T. DONTA & MARK KING

  2. University of Oxford Medical School, Oxford

    KATHRYN SLOPER

Authors
  1. SAM T. DONTA
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. MARK KING
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. KATHRYN SLOPER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

DONTA, S., KING, M. & SLOPER, K. Induction of Steroidogenesis in Tissue Culture by Cholera Enterotoxin. Nature New Biology 243, 246–247 (1973). https://doi.org/10.1038/newbio243246a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio243246a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing