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Inhibitory Effect of Interferon Preparations and Inducers on the Multiplication of Transplanted Allogeneic Spleen Cells and Syngeneic Bone Marrow Cells

Nature New Biology volume 242, pages 152–153 (1973)Cite this article

Abstract

Interferon preparations exhibit a marked antitumour effect in mice inoculated with allogeneic or syngeneic transplantable tumours1–4. The question arises whether this inhibitory effect is restricted to neoplastic cells or whether interferon also inhibits the multiplication of normal cells in vivo. Although it inhibited the division of normal mouse cells in vitro (refs. 5–7, and M. Ohwaki, Y. Kawade and E. Knight, personal communication), daily inoculation of concentrated interferon preparations did not affect the growth or development of newborn mice8. We have investigated the effect of interferon and interferon inducers on the proliferation of allogeneic spleen cells or syngeneic bone marrow cells injected into heavily-irradiated mice.

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References

  1. Gresser, I., Bourali, C., Lévy, J. P., Fontaine-Brouty-Boyé, D., and Thomas, M. T., Proc. US Nat. Acad. Sci., 63, 51 (1969).

    Article  CAS  Google Scholar 

  2. Gresser, I., and Bourali, C., Nature, 223, 844 (1969).

    Article  CAS  PubMed  Google Scholar 

  3. Gresser, I., and Bourali, C., J. Nat. Cancer Inst., 45, 365 (1970).

    CAS  PubMed  Google Scholar 

  4. Gresser, I., and Bourali-Maury, C., Nature New Biology, 236, 78 (1972).

    Article  CAS  PubMed  Google Scholar 

  5. Lindahl-Magnusson, P., Leary, P., and Gresser, I., Proc. Soc. Exp. Biol. Med., 138, 1044 (1971).

    Article  CAS  PubMed  Google Scholar 

  6. Lindahl-Magnusson, P., Leary, P., and Gresser, I., Nature New Biology, 237, 120 (1972).

    Article  CAS  PubMed  Google Scholar 

  7. McNeill, A., and Fleming, W. A., Immunology, 21, 761 (1971).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Gresser, I., and Bourali, C., Europ. J. Cancer, 6, 553 (1970).

    Article  CAS  Google Scholar 

  9. Cerottini, J.-C., Nordin, A. A., and Brunner, K. T., J. Exp. Med., 134, 553 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Brunner, K. T., Mauel, J., Cerottini, J.-C., and Chapuis, B., Immunology, 14, 181 (1968).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Finter, N. B., Nature, 204, 1114 (1964).

    Article  CAS  PubMed  Google Scholar 

  12. Chany, C., and Vignal, M., CR Acad. Sci., 267, 1789 (1968).

    Google Scholar 

  13. Baron, S., and Buckler, C. E., Science, 141, 1061 (1963).

    Article  CAS  PubMed  Google Scholar 

  14. Ho, M., in Interferon (edit. by Finter, N. B.), 21 (North-Holland Publishing, Amsterdam, 1966).

    Google Scholar 

  15. Gresser, I., Fontaine-Brouty-Boyé, D., Bourali, C., and Thomas, M. T., Proc. Soc. Exp. Biol. Med., 130, 236 (1969).

    Article  CAS  PubMed  Google Scholar 

  16. Cerottini, J.-C., and Brunner, K. T., in In Vitro Methods in Cellmediated Immunity (edit. by Bloom, B., and Glade, P.), 369 (Academic Press, NY, 1971).

    Google Scholar 

  17. Gershon, R. K., and Hencin, R. S., J. Immunol., 107, 1723 (1971).

    CAS  PubMed  Google Scholar 

  18. Fontaine-Brouty-Boyé, D., Gresser, I., Macieira-Coelho, A., Rosenfeld, C., and Thomas, M. T., CR Acad. Sci., 269, 406 (1969).

    Google Scholar 

  19. Gresser, I., Brouty-Boyé, D., Thomas, M. T., and Macieira- Coelho, A., Proc. US Nat. Acad. Sci., 66, 1052 (1970).

    Article  CAS  Google Scholar 

  20. Gresser, I., Brouty-Boyé, D., Thomas, M. T., and Macieira-Coelho, A., J. Nat. Cancer Inst., 45, 1145 (1970).

    CAS  PubMed  Google Scholar 

  21. Macieira-Coelho, A., Brouty-Boyé, D., Thomas, M. T., and Gresser, I., J. Cell Biology, 48, 415 (1971).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Swiss Institute for Experimental Cancer Research, Lausanne

    J.-C. CEROTTINI & K. T. BRUNNER

  2. Institut de Recherches Scientifiques sur le Cancer, 94, V illejuif

    P. LINDAHL & I. GRESSER

Authors
  1. J.-C. CEROTTINI
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  2. K. T. BRUNNER
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  3. P. LINDAHL
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  4. I. GRESSER
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CEROTTINI, JC., BRUNNER, K., LINDAHL, P. et al. Inhibitory Effect of Interferon Preparations and Inducers on the Multiplication of Transplanted Allogeneic Spleen Cells and Syngeneic Bone Marrow Cells. Nature New Biology 242, 152–153 (1973). https://doi.org/10.1038/newbio242152a0

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