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Antibody-dependent Cell-mediated Cytotoxicity due to a “Null” Lymphoid Cell


ANTIBODY-COATED target cells may be killed by suspensions of lymphoid cells after depletion of active phagocytes1–4. Harding et al.5 and Van Boxel et al.6 also report that a non-thymus-derived lymphocyte is responsible for this antibody-dependent cell-mediated cytotoxicity in both the rat and mouse. The further observations that the cytotoxic cell acts through an Fc receptor4 similar to that found on most immunoglobulin (Ig)-bearing cells7,8, and that it can be inhibited by pretreatment with anti-Ig sera6, have led some investigators6 to suggest that this cell is a B lymphocyte. The following experiments, however, describe the cytotoxic effector cell as a non-Ig-bearing lymphoid cell which is not of T cell origin.

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GREENBERG, A., HUDSON, L., SHEN, L. et al. Antibody-dependent Cell-mediated Cytotoxicity due to a “Null” Lymphoid Cell. Nature New Biology 242, 111–113 (1973).

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