Abstract
WHEN unavoidable electric footshocks are delivered to two rats in an enclosure, they engage in species-specific stereotyped fighting behaviour1, and a significant decrease in tail blood pressure ensues2. Conversely, when the same shocks are delivered to single rats alone in the cage, only disorganized escape behaviour is displayed and a significant increase in blood pressure ensues2. The reversal of the blood pressure response to shock in pairs, from a significant decrease to a significant increase, produced by intravenous 6-hydroxydopa-mine (6-OHDA) indicated the need for intact peripheral sympathetic nerve terminals for blood pressure to decrease after shock-induced fighting (our work in preparation). We report here an investigation of the role of central nervous system (CNS) catecholamines, using intracisternally administered 6-OHDA.
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WILLIAMS, R., EICHELMAN, B. & NG, L. Depletion of Brain Amines reverses Blood Pressure Response to Footshock in Rat. Nature New Biology 240, 276–277 (1972). https://doi.org/10.1038/newbio240276a0
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DOI: https://doi.org/10.1038/newbio240276a0
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