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Regulation of Normal and Leukaemic Lymphocyte Transformation and Recirculation by Sodium Periodate Oxidation and Sodium Borohydride Reduction

Nature New Biology volume 240, pages 252–255 (1972)Cite this article

Abstract

MANY mitogenic agents1–5 when added to lymphocytes in vitro bind to saccharide-containing sites on cell membranes and cause blast transformation and subsequent incorporation of DNA precursors. Recently it has been observed by Novogrodsky and Katchalski6, using rat lymph node cells, and by Parker et al.7, using human peripheral blood cells, that preincubation with sodium periodate (NaIO4), an oxidizing agent, induces blastogenesis comparable with that observed with phytohaemagglutinin (PHA).

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Author notes

  1. MARION M. ZATZ

    Present address: Departments of Surgery and Microbiology, Yale University School of Medicine, New Haven, Connecticut, 06510

  2. ALLAN L. GOLDSTEIN

    Present address: Division of Biochemistry, Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas, 77550

  3. OLGA O. BLUMENFELD

    Present address: Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, 10461

  4. ABRAHAM WHITE

    Present address: Syntex Research, Stanford Industrial Park, Palo Alto, California, 94304

Authors and Affiliations

  1. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, 10461

    MARION M. ZATZ, ALLAN L. GOLDSTEIN, OLGA O. BLUMENFELD & ABRAHAM WHITE

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  1. MARION M. ZATZ
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ZATZ, M., GOLDSTEIN, A., BLUMENFELD, O. et al. Regulation of Normal and Leukaemic Lymphocyte Transformation and Recirculation by Sodium Periodate Oxidation and Sodium Borohydride Reduction. Nature New Biology 240, 252–255 (1972). https://doi.org/10.1038/newbio240252a0

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  • DOI: https://doi.org/10.1038/newbio240252a0

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