Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Size Requirement of Polyinosinic Acid for DNA Synthesis, Viral Resistance, and Increased Survival of Leukaemic Mice

Nature New Biology volume 240, pages 250–252 (1972)Cite this article

Abstract

THIS study correlates the molecular size requirements of polyinosinic acid (poly I) and polyacrylic acid in four systems: (a) release of restrictions on nuclear DNA template activity; (b) prolongation of the survival time of mice inoculated with L1210 leukaemia cells; (c) production of interferon-like substances in the mouse; and (d) induction of viral resistance in cultured mouse fibroblasts (L929).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kraemer, R. J., and Coffey, D. S., Biochim. Biophys. Acta, 224, 553 (1970).

    Article  CAS  Google Scholar 

  2. Brown, D. G., and Coffey, D. S., Science, 171, 176 (1971).

    Article  CAS  Google Scholar 

  3. Brown, D. G., and Coffey, D. S., Biochem. Biophys. Res. Commun., 42, 326 (1971).

    Article  CAS  Google Scholar 

  4. Tytell, A. A., Lampson, G. P., Field, A. K., Nemes, M. M., and Hilleman, M. R., Proc. Soc. Exp. Biol. Med., 135, 917 (1970).

    Article  CAS  Google Scholar 

  5. Pitha, P. M., and Carter, W. A., Nature New Biology, 234, 105 (1971).

    Article  CAS  Google Scholar 

  6. Wacker, A., Singh, A., Svec, A. J., and Lodemann, E., Naturwissenschaften, 56, 638 (1969).

    Article  CAS  Google Scholar 

  7. Niblack, J. F., and McCreary, M. B., Nature New Biology, 233, 52 (1971).

    Article  CAS  Google Scholar 

  8. Zeleznick, L. D., and Bhuyan, B. K., Proc. Soc. Exp. Biol. Med. 130, 126 (1969).

    Article  CAS  Google Scholar 

  9. Gresser, I., Thomas, M. T., and Brouty-Boye, D., Nature New Biology, 231, 20 (1971).

    CAS  PubMed  Google Scholar 

  10. Levy, H. B., Adamson, R., Carbone, P., DeVita, V., Gazdar, A., Rhim, J., Weinstein, A., and Riley, F., Biological Effects of Polynucleotides (edit. by Beers, R. F., and Braun, W.), 55 (Springer-Verlag, New York, 1971).

    Book  Google Scholar 

  11. Weistein, A. J., Gazdar, A. F., Sims, H. L., and Levy, H. B., Nature New Biology, 231, 53 (1971).

    Article  Google Scholar 

  12. Cancer Chemotherapy National Service Center, Cancer Chemotherapy Reports, 25, 1 (1962).

  13. Wang, A. C., and Kallenbach, N. R., J. Mol. Biol., 62, 591 (1971).

    Article  CAS  Google Scholar 

  14. Matsuda, S., Kida, M., Shirafuji, H., Yoneda, M., and Yaoi, H., Arch. Ges. Virusforsch., 34, 105 (1971).

    Article  CAS  Google Scholar 

  15. DeClercq, E., and Merigan, T. C., Nature, 222, 1148 (1969).

    Article  CAS  Google Scholar 

  16. DeClercq, E., and DeSomer, P., J. Virol., 9, 721 (1972).

    CAS  Google Scholar 

  17. Schell, P. L., Biochim. Biophys. Acta, 240, 472 (1971).

    Article  CAS  Google Scholar 

  18. DeClercq, E., and DeSomer, P., Science, 173, 260 (1971).

    Article  CAS  Google Scholar 

  19. Pitha, J., and Pitha, P. M., Science, 172, 1146 (1971).

    Article  CAS  Google Scholar 

  20. DeClerq, E., Wells, R. D., and Merigan, T. C., Virology, 47, 45 (1972).

    Google Scholar 

  21. Merigan, T. C., and Finkelstein, M. S., Virology, 35, 363 (1968).

    Article  CAS  Google Scholar 

  22. Niblack, F. J., Annals NY Acad. Sci., 173, 536 (1970).

    Article  CAS  Google Scholar 

  23. Boedtker, H., Methods in Enzymology XIIB. (edit. by Grossman, L., and Moldave, K.), 429 (Academic Press, New York, 1968).

    Google Scholar 

  24. Brown, D. G., and Coffey, D. S., J. Biol. Chem. (in the press).

Download references

Author information

Author notes

  1. D. G. BROWN

    Present address: Department of Pharmacology, Southern Illinois University School of Dental Medicine, Edwardsville, Illinois, 62025

Authors and Affiliations

  1. Department of Pharmacology and Experimental Therapeutics, The Johns Hopkins University School of Medicine,

    S. J. MOHR, D. G. BROWN & D. S. COFFEY

  2. The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland, 21205

    S. J. MOHR, D. G. BROWN & D. S. COFFEY

Authors
  1. S. J. MOHR
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. G. BROWN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. S. COFFEY
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MOHR, S., BROWN, D. & COFFEY, D. Size Requirement of Polyinosinic Acid for DNA Synthesis, Viral Resistance, and Increased Survival of Leukaemic Mice. Nature New Biology 240, 250–252 (1972). https://doi.org/10.1038/newbio240250a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio240250a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing