Abstract
THE concept of stringent control has been almost exclusively applied to the amino-acid regulation of RNA synthesis1. It has been widely accepted that the genetic locus responsible for this control is the rel gene on the E. coli chromosome2. In a previous paper3, however, we have suggested that the function of rel gene is not to control directly RNA synthesis, but to facilitate the normal synthesis of protein when the supply of ammo-acids is limited, and that the loss of the stringent control in rel- cells is the consequence of the inhibition of normal protein synthesis in amino-acid starved conditions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
We are sorry, but there is no personal subscription option available for your country.
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Cold Spring Harbor Symp. Quant. Biol., XXXV, 383, 415 (1970).
Edlin, G., and Broda, P., Bact. Rev., 32, 206 (1968).
Sokawa, Y., Sokawa, J., and Kaziro, Y., Nature New Biology, 234, 7 (1971).
Nashimoto, H., Held, W., Kaltshmidt, E., and Nomura, M., J. Mol. Biol., 62, 121 (1971).
Atherly, A. G., and Suchanek, M. C., J. Bacterial., 108, 627 (1971).
Cronan, J. E., and Vagelos, P. R., Biochim. Biophys. Acta, 265, 25 (1972).
Broda, P., J. Bacteriol., 96, 1528 (1968).
Sokawa, Y., Nakao, E., and Kaziro, Y., Biochem. Biophys. Res. Commun., 33, 108 (1968).
Sokawa, Y., and Kaziro, Y., Biochem. Biophys. Res. Commun., 34, 99 (1969).
Sokawa, Y., Nakao-Sato, E., and Kaziro, Y., Biochim. Biophys. Acta, 199, 256 (1970).
Fiil, K., and Friesen, J. D., J. Bacteriol., 95, 729 (1968).
Folch, J., Lees, M., and Sloane-Stanley, G. H., J. Biol. Chem., 226, 497 (1957).
Gray, G. M., Biochim. Biophys. Acta, 144, 511 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SOKAWA, J., SOKAWA, Y. & KAZIRO, Y. Stringent Control in Escherichia coli. Nature New Biology 240, 242–245 (1972). https://doi.org/10.1038/newbio240242a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/newbio240242a0
This article is cited by
-
RelA1 gene control of Escherichia coli lipid structure and cell performance during glucose limited fed-batch conditions
Applied Microbiology and Biotechnology (2006)
-
Inhibitory action of erythromycin on bacteriophage SPO1 multiplication in sporulating cells of Bacillus subtilis 168
Molecular and General Genetics MGG (1980)
-
Role of rel gene in translation during amino acid starvation in Escherichia coli
Nature (1974)
