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Collagen Defect induced by Penicillamine

Nature New Biology volume 240, pages 220–221 (1972)Cite this article

Abstract

ALDEHYDES derived from lysine are involved in the crosslinking of collagen and elastin1–3 and abnormalities in crosslinking can be induced by lathyrogens such as β-amino-propionitrile, isonicotinic acid hydrazide and semicarbazide4,5 as well as by D-penicillamine6,7. Lathyrogens seem to inhibit aldehyde synthesis by irreversibly inactivating a lysyl oxidase in connective tissue8. Although penicillamine at the usual dosage does not affect the activity of this enzyme, it seems to prevent crosslinking by binding to the peptide-bound aldehydes on collagen9.

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Authors and Affiliations

  1. Rheumatic Disease Section, Department of Medicine, University of Southern California, Los Angeles, California, 90033

    M. E. NIMNI, K. DESHMUKH & N. GERTH

Authors
  1. M. E. NIMNI
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  2. K. DESHMUKH
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  3. N. GERTH
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NIMNI, M., DESHMUKH, K. & GERTH, N. Collagen Defect induced by Penicillamine. Nature New Biology 240, 220–221 (1972). https://doi.org/10.1038/newbio240220a0

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