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Evidence for a Fibroblast Chalone

Nature New Biology volume 240, pages 210–211 (1972)Cite this article

Abstract

THE concept of a negative feedback inhibitor being involved in the control of mitosis was proposed by Weiss1, and was applied by Bullough and Laurence2 to their interpretation of experimental evidence accumulated in studying the control of epidermal mitoses. They proposed that epidermal cells (and presumably many other cell types) would contain or release a specific and endogenous mitotic inhibitor which they termed a “chalone”. Their definition of this term included the reversibility of the mitotic inhibition as well as its total cell specificity2. Their experience indicated that the epidermal chalone was neither species specific nor cytotoxic2,3. Specific endogenous mitotic inhibitors have been claimed for a number of other cells including lymphocytes4–6 and granulocytes7.

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References

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Authors and Affiliations

  1. Biochemistry Research Laboratory, Children's Hospital, DC

    J. C. HOUCK, R. L. WEIL & V. K. SHARMA

  2. Department of Child Health and Development, George Washington University Medical Center, Washington, DC

    J. C. HOUCK, R. L. WEIL & V. K. SHARMA

Authors
  1. J. C. HOUCK
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  2. R. L. WEIL
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  3. V. K. SHARMA
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HOUCK, J., WEIL, R. & SHARMA, V. Evidence for a Fibroblast Chalone. Nature New Biology 240, 210–211 (1972). https://doi.org/10.1038/newbio240210a0

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  • DOI: https://doi.org/10.1038/newbio240210a0

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