Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Particulate Form of DNA Polymerase in Rat Brain

Abstract

THE amount of DNA in rat brain was reported to be maximal at 16–18 days after birth1–3, and in the adult brain to exhibit little or no DNA synthesis and little DNA polymerase activity3–6. We have found in adult rat brain nuclei, however, a very high DNA polymerase activity in a particulate form, and this activity cannot usually be detected7.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Mandel, P., Rein, H., Harth-Edel, S., & Mardell, R., in Comparative Neurochemistry (edit. by Richter, D.), 149 (Pergamon, Oxford, 1964).

    Book  Google Scholar 

  2. McIIwain, M., in Biochemistry and the Central Nervous System (third edition), 270 (Churchill, London, 1966).

    Google Scholar 

  3. Adams, D. H., Biochem. J., 98, 636 (1966).

    Article  CAS  Google Scholar 

  4. Sung, S. C., Canadian J. Biochem., 47, 47 (1969).

    Article  CAS  Google Scholar 

  5. Altman, J., J. Comp. Neurol., 128, 431 (1966).

    Article  Google Scholar 

  6. Chiu, J. F., & Sung, S. C., Biochim. Biophys. Acta, 209, 34 (1970).

    Article  CAS  Google Scholar 

  7. Chiu, J. F., & Sung, S. C., Biochim. Biophys. Acta, 262, 397 (1972).

    Article  CAS  Google Scholar 

  8. Mandel, P., David, A. R., & Pete, N., J. Neurochem., 14, 301 (1967).

    Article  CAS  Google Scholar 

  9. Chiu, J. F., & Sung, S. C., Biochim. Biophys. Acta, 246, 44 (1971).

    Article  CAS  Google Scholar 

  10. Bollum, F. J., & Potter, V. R., J. Biol. Chem., 233, 478 (1958).

    CAS  PubMed  Google Scholar 

  11. Chiu, J. F., & Sung, S. C., Biochem. Biophys. Res. Commun., 46, 1830 (1972).

    Article  CAS  Google Scholar 

  12. Comings, D. E., & Kaefuda, T., J. Mol. Biol., 33, 225 (1968).

    Article  CAS  Google Scholar 

  13. Pawlowski, P. J., & Berlowitz, L., Exp. Cell Res., 56, 154 (1969).

    Article  CAS  Google Scholar 

  14. Kay, R. R., Haines, M. E., & Johnston, I. R., FEBS Lett., 16, 233 (1971).

    Article  CAS  Google Scholar 

  15. Martin, R. G., & Ames, B. N., J. Biol. Chem., 236, 1372 (1961).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CHIU, JF., SUNG, S. Particulate Form of DNA Polymerase in Rat Brain. Nature New Biology 239, 176–178 (1972). https://doi.org/10.1038/newbio239176a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio239176a0

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing