Abstract
LYSOSOMAL enzymes are important mediators of the inflammatory process1. Soluble extracts of purified leucocyte lysosomes elicit cutaneous and joint inflammations2, and degrade the protein-mucopolysaccharide matrix of cartilage3. Activities of acid hydrolases are elevated significantly in inflamed tissues, including rheumatoid synovial membranes4–7. The hydrolytic degradation of cartilage protein-mucopolysaccharide, which underlies the inflammatory pannus of rheumatoid joints, may be provoked by lysosomal enzymes released from cells that are phagocytosing immune complexes within the pannus8,9.
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IGNARRO, L., COLOMBO, C. Enzyme Release from Guinea-pig Polymorphonuclear Leucocyte Lysosomes Inhibited in vitro by Anti-Inflammatory Drugs. Nature New Biology 239, 155–157 (1972). https://doi.org/10.1038/newbio239155a0
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DOI: https://doi.org/10.1038/newbio239155a0
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