Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Thymus and Bursa Dependence of Lymphocyte Mitogenic Factor in the Chicken

Nature New Biology volume 239, pages 137–139 (1972)Cite this article

Abstract

AMONG the soluble products generated during activation of rodent or human lymphocytes1, lymphocyte-stimulating (‘mitogenic’) factors are detected by their ability to accelerate DNA metabolism of freshly cultured allogeneic or syngeneic lymphocytes2–8. If such lymphocyte activation products function as mediators of cellular immunity1,9–11, their activities will be generated independently of the antibody-forming system. In the chicken, antigen-stimulation of sensitized lymphocytes in vitro involves both thymus (T-) and bursa-(B-)-dependent cells12–14. If antigen-induced lymphocyte transformations are generally mediated by lymphocyte mitogenic factors, both T-cells and B-cells should produce lymphocyte mitogenic factors when stimulated by specific antigen. We have therefore determined whether antigen-stimulated chicken lymphocytes generate a lymphocyte mitogenic factor and whether this response is affected by neonatal thymectomy or bursectomy.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bloom, B. R., Adv. Immunol, 14, 268 (1971).

    Google Scholar 

  2. Kaskakura, S., & Lowenstein, L., Nature, 208, 794 (1965).

    Article  Google Scholar 

  3. Maini, R. N., Bryceson, A. D. M., Wolstencroft, R. A., & Dumonde, D. C., Nature, 224, 43 (1969).

    Article  CAS  Google Scholar 

  4. Valentine, F. T., & Lawrence, H. S., Science, 165, 1014 (1969).

    Article  CAS  Google Scholar 

  5. Wolstencroft, R. A., & Dumonde, D. C., Immunology, 18, 597 (1970).

    Google Scholar 

  6. Kasakura, S., J. Immunol., 105, 1162 (1970).

    CAS  PubMed  Google Scholar 

  7. Spitler, L. E., & Lawrence, H. S., J. Immunol., 103, 1072 (1969).

    CAS  PubMed  Google Scholar 

  8. Havermann, K., & Bürger, S., Eur. J. Immunol., 1, 285 (1971).

    Article  Google Scholar 

  9. Dumonde, D. C., Wolstencroft, R. A., Panayi, G. S., Matthew, M., Morley, J., & Howson, W. T., Nature, 224, 38 (1969).

    Article  CAS  Google Scholar 

  10. Moller, G., Cell. Immunol., 1, 110 (1970).

    Article  CAS  Google Scholar 

  11. Kelly, R. H., Wolstencroft, R. A., Dumonde, D. C., & Balfour, B. M., Clin. Exp. Immunol., 10, 49 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Alm, G. V., Int. Arch. Allergy, 40, 643 (1971).

    Article  CAS  Google Scholar 

  13. Meuwissen, N. J., Alten, P. J. V., & Good, R. A., J. Immunol. 102, 1079 (1969).

    CAS  PubMed  Google Scholar 

  14. Alm, G. V., Int. Arch. Allergy, 41 (in the press, 1972).

  15. Alten, P. J. V., Good, R. A., & Meuwissen, H. J., Int. Arch Allergy, 35, 381 (1969).

    Article  Google Scholar 

  16. Peterson, R. D. A., Burmester, B. R., & Fredrickson, J. N., J. Natl. Cancer Inst., 32, 1343 (1964).

    Article  CAS  Google Scholar 

  17. Payne, L. N., & Rennie, M., J. Natl Cancer Inst., 45, 387 (1970).

    CAS  PubMed  Google Scholar 

  18. Purchase, H. G., Poultry Sci., 46, 1017 (1967).

    Article  CAS  Google Scholar 

  19. Steel, R. G. D., & Torrie, J. H., Principles and Procedures of Statistics (McGraw-Hill, London, 1960).

    Google Scholar 

  20. Greaves, M. F., Roitt, I. M., & Rose, M. E., Nature, 220, 393 (1968).

    Article  Google Scholar 

  21. Dumonde, D. C., & Maini, R. N., Clin. Allergy, 1, 123 (1971).

    Article  CAS  Google Scholar 

  22. Droege, W., Nature, 234, 549 (1971).

    Article  CAS  Google Scholar 

  23. Andersson, J., Moller, G., & Sjöberg, O., Eur. J. Immunol, 2, (1972), in the press.

  24. Allison, A. C., Denman, M., & Barnes, R. D., Lancet, ii, 135 (1971).

  25. Moller, G., Clin. Exp. Immunol., 4, 65 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Mackler, B. F., Wolstencroft, R. A., & Dumonde, D. C., Nature New Biology, 239, 139 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisions of Immunology and Clinical Research, Kennedy Institute of Rheumatology, Hammersmith, London, W6 7DW

    CAROLYN M. OATES, J. F. BISSENDEN & R. N. MAINI

  2. Houghton Poultry Research Station, Houghton, Huntingdon

    L. N. PAYNE & D. C. DUMONDE

Authors
  1. CAROLYN M. OATES
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. F. BISSENDEN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R. N. MAINI
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. N. PAYNE
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. D. C. DUMONDE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

OATES, C., BISSENDEN, J., MAINI, R. et al. Thymus and Bursa Dependence of Lymphocyte Mitogenic Factor in the Chicken. Nature New Biology 239, 137–139 (1972). https://doi.org/10.1038/newbio239137a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio239137a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing