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Diphasic Glucagon Release Induced by Arginine in the Perfused Rat Pancreas

Nature New Biology volume 239, pages 125–126 (1972)Cite this article

Abstract

A DIPHASIC pattern has been recorded for insulin release after glucose stimulation in rat pancreas1 and in man2, and also after arginine stimulation in man3: this led to the concept of a two-compartmental storage system for insulin1. A diphasic pattern of secretion might be expected in some other endocrine cell types. To check this possibility for alpha-2 cells, perfused rat pancreas was submitted to both continuous infusion and pulses of a demonstrated glucagon stimulator, arginine4; glucagon responses were then measured.

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References

  1. Grodsky, G. M., Lee, J., Licko, V., & Landahl, H., Proc. Seventh Cong. Inter. Diab. Fed., Buenos Ayres, August 1970 (edit. by Rodriguez, R. R., and Vallance, Owen, J.) in Excerpta Med., 427 (Amsterdam, 1971).

  2. Cerasi, E., & Luft, R., Diabetes, 16, 615 (1967).

    Article  CAS  Google Scholar 

  3. Fajans, S. S., Floyd, J. C., Knopf, R. F., Pek, S., Quibreria, R., & Conn, J. W., Proc. Seventh Cong. Inter. Diab. Fed., Buenos Ayres, August 1970 (edit. by Rodriguez, R. R., and Vallance Owen, J.), in Excerpta Med., 123 (Amsterdam, 1971).

  4. Assan, R., Rosselin, G., & Dolais, J., J. Annuell. Diabet. (edit. by Flammarion), 26 (Hôtel-Dieu, Paris, 1967).

    Google Scholar 

  5. Sussman, K. E., Vaughan, G. D., & Timmer, R. F., Diabetes, 15, 521 (1966).

    Article  Google Scholar 

  6. Assan, R., Tchobroutsky, G., & Derot, M., Hormone Metab. Res., Suppl. No. 3, 82 (1971).

  7. Berson, S. A., & Yalow, R. S., J. Clin. Invest., 40, 1803 (1961).

    Article  CAS  Google Scholar 

  8. Tiengo, A., Assan, R., & Tchobroutsky, G., Diabetes (in the press).

  9. Assan, R., Hanoune, J., & Attali, J. R., Proc. Seventh Eur. Ass. Study Diab. Ann. Meeting, 9 (Southampton, 1971).

  10. Unger, R. H., Ohneda, A., Aguilar-Parada, E., & Eisentraut, A. M., J. Clin. Invest., 48, 810 (1969).

    Article  CAS  Google Scholar 

  11. Marreiro, D. M., Faloona, G. R., & Unger, R. H., Proc. Ann. Meeting Amer. Fed. Clin. Res. (New Orleans, January 27, 1972).

    Google Scholar 

  12. Christensen, H. N., Cullen, A. M., Harrison, L. I., Fajans, S. S., & Pek, S., in Physiology and Pharmacology of Cyclic AMP, an Internat. Conference, 81 (Milan, July 1971).

    Google Scholar 

  13. Luyckz, A. S., Massi-Benedetti, F., & Lefebvre, P. J., Proc. Seventh Ann. Europ. Assoc. Study Diabetes Meeting, 115 (Southampton, 1971).

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Authors and Affiliations

  1. Hôpital Hôtel-Dieu, Paris

    R. ASSAN, J. BOILLOT & J. R. ATTALI

  2. Faculté de Sciences, Paris

    E. SOUFFLET

  3. University of Parma,

    G. BALLERIO

Authors
  1. R. ASSAN
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  2. J. BOILLOT
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  3. J. R. ATTALI
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  4. E. SOUFFLET
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  5. G. BALLERIO
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ASSAN, R., BOILLOT, J., ATTALI, J. et al. Diphasic Glucagon Release Induced by Arginine in the Perfused Rat Pancreas. Nature New Biology 239, 125–126 (1972). https://doi.org/10.1038/newbio239125a0

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